Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second
Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second
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DOI：
10.1364/oe.18.014685
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发表时间：
2010-07-05
期刊：
影响因子：
3.8
通讯作者：
Huber, Robert
中科院分区：
文献类型：
--
作者：
Wieser, Wolfgang;Biedermann, Benjamin R.;Huber, Robert
我们提出了超高速光学相干断层扫描（OCT）与兆赫线率和研究可实现的图像质量。提出的系统是一个扫描源OCT设置使用傅里叶域模式锁定（FDML）激光器。对扫描速率分别为1、2.6和5.2MHz的三种不同的fdml扫描激光源进行了比较。4个点并行成像使有效速度提高了四倍，使深度扫描速率高达每秒2080万行。每个设置提供至少98dB的灵敏度和类似于10 μ m的组织分辨率。高质量的二维和三维成像的生物样品演示在全扫描速度。讨论了如何最好地指定OCT成像速度。给出了体素率、线率、帧率与OCT硬件性能之间的关系，如采样率、模拟带宽、相干长度、采集死区时间和扫描仪占空比。最后讨论了进一步提高图像质量的平均算法。(C) 2010年美国光学学会
We present ultra high speed optical coherence tomography (OCT) with multi-megahertz line rates and investigate the achievable image quality. The presented system is a swept source OCT setup using a Fourier domain mode locked (FDML) laser. Three different FDML-based swept laser sources with sweep rates of 1, 2.6 and 5.2MHz are compared. Imaging with 4 spots in parallel quadruples the effective speed, enabling depth scan rates as high as 20.8 million lines per second. Each setup provides at least 98dB sensitivity and similar to 10 mu m resolution in tissue. High quality 2D and 3D imaging of biological samples is demonstrated at full scan speed. A discussion about how to best specify OCT imaging speed is included. The connection between voxel rate, line rate, frame rate and hardware performance of the OCT setup such as sample rate, analog bandwidth, coherence length, acquisition dead-time and scanner duty cycle is provided. Finally, suitable averaging protocols to further increase image quality are discussed. (C) 2010 Optical Society of America