Synthesis of the Naturally Occurring (-)-1,3,5-Tri-O-Caffeoylquinic Acid.
Synthesis of the Naturally Occurring (-)-1,3,5-Tri-O-Caffeoylquinic Acid.
复制标题
DOI：
10.1055/s-0029-1217183
复制
发表时间：
2009-02-11
期刊：
影响因子：
--
通讯作者：
Deforrest JE
中科院分区：
文献类型：
--
作者：
Brummond KM;Deforrest JE
核糖核酸酶H （RNase H）是人类免疫缺陷病毒（HIV）复制的重要组成部分，目前已知的这种酶的抑制剂很少。Millenia Hope制药公司发现(-)-1,3,5-三- o -咖啡酰奎宁酸是一种有效的RNase H抑制剂和抗病毒药物。从市售的(-)-奎宁酸中获得这种抑制剂的简单途径已在国内报道。
Ribonuclease H (RNase H) is an essential component to the replication of human immunodeficiency virus (HIV), and only a few inhibitors of this enzyme are known. Millenia Hope Pharmaceuticals Inc. found that (–)-1,3,5-tri-O-caffeoylquinic acid is a potent RNase H inhibitor and antiviral agent. A facile route leading to this inhibitor from commercially available (–)-quinic acid is reported within.