Automated Hippocampal Subfield Segmentation in Amnestic Mild Cognitive Impairments
Automated Hippocampal Subfield Segmentation in Amnestic Mild Cognitive Impairments
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DOI：
10.1159/000339588
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发表时间：
2012-01-01
影响因子：
2.4
通讯作者：
Lee, Chang Uk
中科院分区：
文献类型：
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作者：
Lim, Hyun Kook;Hong, Seung Chul;Lee, Chang Uk
虽然已经开发了一些自动的海马子场分割方法，但在磁共振成像(MRI)上，遗忘性轻度认知损害对海马子场体积的影响尚不清楚。本研究的目的是利用海马区自动分割技术，研究急性脑梗塞患者海马区体积的变化及其与各种神经心理测试的关系。对45例aMCI患者和49例健康对照组进行3Tesla磁共振扫描，测量并比较其海马子区体积。此外，我们探索了海马子区体积与韩国版联合体之间的相关模式，以建立一个阿尔茨海默病登记处(CERAD-K)在aMCI受试者中的神经心理测试分数。与健康受试者相比，aMCI受试者在丘脑前区、下丘脑区和腺角2-3区的海马区体积显著减小。此外，我们还发现，在aMCI中，丘脑前区和丘下区体积与CERAD-K语言和视觉空间延迟回忆分数呈显著正相关。本研究首次探讨了不同类型认知行为与海马子区体积之间的关系。这些结构变化可能是急性MCI患者海马区功能障碍的神经生物学机制的核心。版权所有(C)2012 S.Karger AG，巴塞尔
Although a few automated hippocampal subfield segmentation methods have been developed, the effects of amnestic mild cognitive impairment (aMCI) on the hippocampal subfield volumes on magnetic resonance imaging (MRI) are not clear. The aim of this study was to investigate the hippocampal subfield volume changes and their relationships with various neuropsychological tests in aMCI using an automated hippocampal subfield segmentation technique. Forty-five subjects with aMCI and 49 group-matched healthy control subjects underwent 3-tesla MRI scanning, and hippocampal subfield volumes were measured and compared. Additionally, we explored the correlation pattern between hippocampal subfield volumes and the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) neuropsychological test scores in aMCI subjects. Subjects with aMCI exhibited significant hippocampal volume reductions in the presubiculum, subiculum and cornu ammonis 2-3 areas compared with healthy subjects. In addition, we also found significant positive correlations between presubiculum and subicular area volumes and the CERAD-K verbal and visuospatial delayed recall scores in aMCI. This study was the first to explore the relationships between hippocampal subfield volumes and various types of cognitive performances in aMCI. These structural changes might be at the core of the underlying neurobiological mechanisms of hippocampal dysfunction in aMCI. Copyright (C) 2012 S. Karger AG, Basel