Dopamine cell transplantation in Parkinson's disease: challenge and perspective.
Dopamine cell transplantation in Parkinson's disease: challenge and perspective.
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DOI：
10.1093/bmb/ldr040
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发表时间：
2011-12
影响因子：
6.7
通讯作者：
Yilong Ma;S. Peng;V. Dhawan;D. Eidelberg
中科院分区：
文献类型：
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作者：
Yilong Ma;S. Peng;V. Dhawan;D. Eidelberg
背景：功能成像为临床评估帕金森病(PD)细胞修复疗法的疗效提供了有价值的辅助手段。资料来源在本文中，我们综述了正电子发射断层扫描(PET)成像在评估帕金森病患者胚胎多巴胺(DA)细胞移植手术结果方面的最新进展。这些研究表明，在PD患者和实验性帕金森病模型中，纹状体移植胎儿黑质组织后，细胞长期存活和临床受益。移植后的不良事件也引起了争议，并被归因于各种原因。生长点DA细胞移植治疗的最佳结果取决于移植物中DA神经元的组织组成和表型。及时开展研究的领域鉴于近年来干细胞产生DA神经元的持续进展，神经干细胞移植可能是下一个进入患者临床试验的领域。结论胚胎多巴胺移植治疗晚期帕金森病的研究为设计新的细胞治疗方法提供了有价值的启示。
BACKGROUND Functional imaging provides a valuable adjunct to clinical evaluation for assessing the efficacy of cell-based restorative therapies in Parkinson's disease (PD). SOURCES OF DATA In this article, we review the latest advances on the use of positron emission tomography (PET) imaging in evaluating the surgical outcome of embryonic dopamine (DA) cell transplantation in PD patients. AREAS OF AGREEMENT These studies suggest long-term cell survival and clinical benefit following striatal transplantation of fetal nigral tissue in PD patients and in models of experimental parkinsonism. AREAS OF CONTROVERSY Adverse events subsequent to transplantation have also been noted and attributed to a variety of causes. GROWING POINTS Optimal outcomes of DA cell transplantation therapies are dependent on tissue composition and phenotype of DA neurons in the graft. AREAS TIMELY FOR DEVELOPING RESEARCH Given continued progress in DA neuron production from stem cells in recent years, transplantation of neural stem cells may be the next to enter clinical trials in patients. CONCLUSION The existing data from studies of embryonic DA transplantation for advanced PD have provided valuable insights for the design of new cell-based therapies for the treatment of this and related neurodegenerative disorders.