Nanostructured PLLA-Hydroxyapatite Scaffolds Produced by a Supercritical Assisted Technique
Nanostructured PLLA-Hydroxyapatite Scaffolds Produced by a Supercritical Assisted Technique
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DOI：
10.1021/ie8018752
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发表时间：
2009-06-03
影响因子：
4.2
通讯作者：
Cardea, Stefano
中科院分区：
文献类型：
--
作者：
Reverchon, Ernesto;Pisanti, Paola;Cardea, Stefano
临时骨支架可以替代细胞外基质，促进组织和器官的再生。要获得模拟人体骨骼组织所必需的宏观、微观和纳米结构特性的共存是非常困难的。为了获得所有这些特性，我们测试了一种超临界流体辅助技术，使用羟基磷灰石（HA）纳米颗粒负载高达聚合物重量的50%，以形成PLLA/陶瓷支架，以改善支架的生物甲基化和机械性能。我们在相对较短的时间内生产出聚l -乳酸支架(
Temporary bone scaffolds can surrogate the extracellular matrix to favor the regeneration of tissues and organs. It is very difficult to obtain the coexistence of the macro-, micro-, and nanostructural properties necessary to mimic the organization of the human bone. To obtain all of these characteristics, we tested a supercritical fluid assisted technique for the formation of PLLA/ceramic scaffolds using hydroxyapatite (HA) nanoparticles loaded at up to 50% by weight of the polymer to improve the biomimethism and the mechanical properties of the scaffolds. We produced poly(L-lactic acid) scaffolds in relatively short time (