Abdominal obesity is strongly associated with Cardiovascular Disease and its Risk Factors in Elderly and very Elderly Community-dwelling Chinese.
Abdominal obesity is strongly associated with Cardiovascular Disease and its Risk Factors in Elderly and very Elderly Community-dwelling Chinese.
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DOI：
10.1038/srep21521
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发表时间：
2016-02-17
影响因子：
4.6
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Fan H;Li X;Zheng L;Chen X;Lan Q;Wu H;Ding X;Qian D;Shen Y;Yu Z;Fan L;Chen M;Tomlinson B;Chan P;Zhang Y;Liu Z
肥胖通常被认为是动脉粥样硬化性心血管疾病(ASCVD)的易感因素，但在一些老年人群中，轻度肥胖或超重可能具有保护作用。在3950名上海社区老年居民中，21.5%患有ASCVD，56.2%的人体重指数(BMI)为24 kg/m2，50.1%的人有高腰围(WC)，77.1%的人有腰围/身高比(Wit/Height Ratio，≥)。男性和女性的WHtR均随年龄增长而增加，而WC仅在女性中随年龄增长而增加，BMI仅在男性中随年龄增长而下降。经受试者操作特征分析确定的预测腹主动脉粥样硬化风险的最佳WHtR临界值为WHtR≥0.53，患病率为55.8%。腹型肥胖与ASCVD的流行显著相关，WHTRBMI 0.53的优势比值高于高WC，而高≥与高WC无关。所有这三个指数都预示着高血糖、甘油三酯和超敏C反应蛋白水平，但只有WHtR≥0.53显示出与体力活动显著相关。腹型肥胖指数，而不是体重指数，可以预测中国老年人群中ASCVD的流行及其危险因素。
Obesity is usually considered to predispose to atherosclerotic cardiovascular disease (ASCVD) but milder degrees of obesity or overweight may be protective in some elderly populations. We examined the relationships between general and abdominal obesity indices with ASCVD and its risk factors in elderly (aged ≥65 years) Shanghai community residents Among the 3950 participants, 21.5% had ASCVD, 56.2% had body mass index (BMI) ≥24 kg/m2, 50.1% had high waist circumference (WC) and 77.1% had waist-to-height ratio (WHtR) ≥0.50. WHtR increased with age in both men and women whereas WC increased with age only in women and BMI decreased with age only in men. The optimal WHtR cut-off value to predict the risk of ASCVD determined by receiver operating characteristic analysis was WHtR ≥0.53 with a prevalence of 55.8%. Having abdominal obesity was significantly associated with prevalent ASCVD with WHtR ≥0.53 having a higher value for the odds ratio than high WC, whereas high BMI was not associated. All three indices predicted high glucose, triglycerides and hsCRP levels but only the WHtR ≥0.53 showed a significant association with physical activity. Abdominal obesity indices, but not BMI, predicted prevalent ASCVD and its risk factors in this elderly Chinese population.