POSTPRANDIAL SERUM BILE-ACIDS IN HEALTHY MAN - EVIDENCE FOR DIFFERENCES IN ABSORPTIVE PATTERN BETWEEN INDIVIDUAL BILE-ACIDS
POSTPRANDIAL SERUM BILE-ACIDS IN HEALTHY MAN - EVIDENCE FOR DIFFERENCES IN ABSORPTIVE PATTERN BETWEEN INDIVIDUAL BILE-ACIDS
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DOI：
10.1136/gut.18.8.606
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发表时间：
1977-01-01
期刊：
影响因子：
24.5
通讯作者：
BJORKHEM, I
中科院分区：
文献类型：
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作者：
ANGELIN, B;BJORKHEM, I
采用高特异性、高准确度的气相色谱-质谱联用技术测定了5名健康女性受试者标准餐前后血清中胆酸（C）、鹅去氧胆酸（CD）和脱氧胆酸（D）的浓度。C在餐后60 min显著升高，90 min达高峰，150 min后恢复至原水平。CD和D在餐后30 min显著升高，90分钟后达到峰值，但150分钟后尚未恢复到空腹水平。餐后血清胆汁酸反应表明，人体小肠近端的二羟基胆汁酸。
The serum concentrations of cholic acid (C), chenodeoxycholic acid (CD) and deoxycholic acid (D) before and after a standardized meal were determined in 5 healthy female subjects using a highly specific and accurate gas chromatographic-mass spectrometric technique. The C level rose significantly 60 min after the meal, reached a peak after 90 min and had returned to the original level after 150 min. The serum concentrations of CD and D displayed a significant rise by 30 min, reached a peak after 90 min but had not returned to fasting levels after 150 min. The serum bile acid responses after a meal suggest that there is considerable absorption of dihydroxy bile acids in the proximal small intestine in man.