ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis.
ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis.
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DOI：
10.7150/jca.12973
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发表时间：
2016
影响因子：
3.9
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Ma X;Huang M;Wang Z;Liu B;Zhu Z;Li C
锌指和同源异型盒1（ZHX 1）与人类癌症的发生有关。然而，关于ZHX 1在胃癌（GC）中的作用知之甚少。在这里，我们发现，与配对的非肿瘤组织相比，ZHX 1在GC组织中下调，并且ZHX 1表达的缺失与GC患者的侵袭性临床特征相关。ZHX 1通过下调cyclin D1和cyclin E的表达诱导G1/S期阻滞，通过下调Bcl 2和上调Bax和Caspase-3的表达诱导细胞凋亡。我们的研究结果表明，ZHX 1可以通过诱导细胞周期阻滞和凋亡来抑制胃癌细胞的生长。
Zinc-fingers and homeoboxes 1 (ZHX1) was implicated in the carcinogenesis of human cancers. However, little is known about the role of ZHX1 in gastric cancer (GC). Here, we found that ZHX1 was downregulated in GC tissues compared with paired non-tumor tissues and loss of ZHX1 expression correlated with aggressive clinical characteristics of GC patients. ZHX1 induced G1/S arrest by decreasing cyclin D1 and cyclin E expression, and induced cell apoptosis by Bcl2 downregulation and Bax and cleaved Caspase-3 upregulation. Our findings revealed that ZHX1 could inhibit cell growth through inducing cell-cycle arrest and apoptosis in GC.