BIOCHEMICAL AND STRUCTURAL-PROPERTIES OF THE CARTILAGE ENDPLATE AND ITS RELATION TO THE INTERVERTEBRAL-DISK
BIOCHEMICAL AND STRUCTURAL-PROPERTIES OF THE CARTILAGE ENDPLATE AND ITS RELATION TO THE INTERVERTEBRAL-DISK
复制标题
DOI：
10.1097/00007632-198902000-00005
复制
发表时间：
1989-02-01
期刊：
影响因子：
3
通讯作者：
URBAN, JPG
中科院分区：
文献类型：
--
作者：
ROBERTS, S;MENAGE, J;URBAN, JPG
软骨终板被认为在椎间盘的营养中起着重要的作用，因此在背痛的病因中可能具有重要意义。本研究描述了年轻成人腰椎终板和邻近组织的生化和组织学特性。因此，一个数据是建立在其中，以证明变化与位置和不同组织的性质之间的关系。化学分析结果表明，与靠近椎间盘的外环和靠近骨的端板相比，端板的成分发生了变化，胶原蛋白含量较高，但蛋白聚糖和水分含量较低。组织学显示沿端板有许多破坏，在几个标本中存在Schmorl淋巴结。与周围组织相比，椎间盘和某些情况下的终板显示蛋白多糖的损失。
The cartilaginous end-plate is thought to play an important role in the nutrition of the intervertebral disc, and hence may be of significance in the etiology of back pain. The present study describes the biochemical and histologic properties of the end-plate and adjacent tissues in the young human adult lumbar spine. Thus, a datum is established in which to demonstrate variation with location and relationships between properties of different tissues. Results of the chemical analyses show a change in composition through the end-plate with that at the outer annulus and nearer the bone, having higher collagen but lower proteoglycan and water contents, than the end-plate nearest the disc at the nucleus. Histology demonstrated numerous disruptions along the end-plate, with Schmorl''s nodes being present in several specimens. Where these occurred, the disc, and in some cases the end-plate, showed loss of proteoglycan compared with the surrounding tissue.