Seroepidemiology of TORCH antibodies in the reproductive-aged women in China
Seroepidemiology of TORCH antibodies in the reproductive-aged women in China
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中国育龄妇女TORCH抗体血清流行病学
DOI：
10.1016/j.ejogrb.2020.09.010
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发表时间：
2020-11-01
影响因子：
2.6
通讯作者：
Ruan, Qiang
中科院分区：
文献类型：
--
作者：
Qi, Ying;Zhu, Shu;Ruan, Qiang
TORCH是弓形虫(TOX)、风疹病毒(RUV)、巨细胞病毒(CMV)和单纯疱疹病毒(HSV)的首字母缩写，是先天性感染的主要原因。关于妇女TORCH血清流行病学的全国性人口流行病学研究尚缺乏，妇女TORCH感染是否与不良妊娠结局有关仍不清楚。本研究以中国地区8家医院的48,406名无症状女性为研究对象，同时对26,400名女性进行了7项TORCH特异性抗体检测。用化学发光免疫分析法检测TORCH免疫球蛋白M(IgM)和/或免疫球蛋白G(Ig G)抗体，以及TOX和CMV Ig M和Ig G阳性血清的Ig G亲和力。育龄妇女TOX、RUV、CMV和HSV-(1+2)抗体总感染率分别为1.71%、81.97%、95.09%和90.15%。TOX、RUV和CMV的相应IgM患病率分别为0.30%、0.89%和0.52%。在调查人群中，原发TOX和CMV感染率至少分别为0.08%(21/26,400)和0.03%(7/26,400)。TORCH阳性妇女在不同年龄、不同季节、不同地区的分布有差异(P
TORCH, the acronym of Toxoplasma gondii (TOX), others, rubella virus (RUV), cytomegalovirus (CMV) and herpes simplex virus (HSV), is a major contributor to congenital infection. National population-based study on the seroepidemiology of TORCH in women is yet lacking, and it is still obscure whether TORCH infection in the women was associated with adverse pregnancy outcomes. A total of 48,406 asymptomatic women from eight hospitals in China which covered the most areas of mainland China were enrolled in this study, and 26,400 were simultaneously subjected to 7 detection tests for TORCH specific antibodies. Chemiluminescent immunoassay was performed to detect TORCH Immunoglobulin M (IgM) and/or Immunoglobulin G (IgG) antibodies, and IgG avidities of TOX and CMV IgM and IgG positive serum samples. The overall IgG prevalence of TOX, RUV, CMV and HSV-(1 + 2) in the reproductive-aged women was 1.71 %, 81.97 %, 95.09 % and 90.15 % respectively. The corresponding IgM prevalence of TOX, RUV and CMV was 0.30 %, 0.89 % and 0.52 %. Moreover, the rates of primary TOX and CMV infections were at least 0.08 % (21/26,400) and 0.03 % (7/26,400) in the studied population. The distributions of TORCH positive women in various age, season and region groups were different (P