Networks that Govern Cardiomyocyte Proliferation to Facilitate Repair of the Injured Mammalian Heart.
Networks that Govern Cardiomyocyte Proliferation to Facilitate Repair of the Injured Mammalian Heart.
复制标题
DOI：
10.14797/mdcvj.1300
复制
发表时间：
2023
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
心血管疾病是全球和美国（US）的头号死因。心血管疾病经常进展为终末期心力衰竭，治愈性治疗非常有限。人们的强烈兴趣集中在破译管理心肌细胞增殖和受损心脏再生的级联和网络上。例如，研究表明，低等生物，如成年蝾螈和成年斑马鱼，有能力完全再生其受损的心脏，恢复功能。类似地，新生小鼠和猪也能够完全再生损伤的心肌，这是由于心肌细胞从预先存在的心肌细胞增殖。使用这些动物模型和转录组分析，努力集中在定义的因素和信号通路，可以重新激活和诱导成年哺乳动物损伤的心脏心肌细胞增殖。这些研究和发现有可能定义新的疗法，以促进心肌细胞增殖和修复受损的哺乳动物心脏。
Cardiovascular diseases are the number one cause of death worldwide and in the United States (US). Cardiovascular diseases frequently progress to end-stage heart failure, and curative therapies are extremely limited. Intense interest has focused on deciphering the cascades and networks that govern cardiomyocyte proliferation and regeneration of the injured heart. For example, studies have shown that lower organisms such as the adult newt and adult zebrafish have the capacity to completely regenerate their injured heart with restoration of function. Similarly, the neonatal mouse and pig are also able to completely regenerate injured myocardium due to cardiomyocyte proliferation from preexisting cardiomyocytes. Using these animal models and transcriptome analyses, efforts have focused on the definition of factors and signaling pathways that can reactivate and induce cardiomyocyte proliferation in the adult mammalian injured heart. These studies and discoveries have the potential to define novel therapies to promote cardiomyocyte proliferation and repair of the injured, mammalian heart.