More stories on Th17 cells.
More stories on Th17 cells.
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二十多年来，免疫学家一直使用所谓的Th 1/Th 2范式来解释与适应性免疫相关的大多数现象。Th 1/Th 2模式意味着存在两种不同的相互调节的CD 4 + T辅助细胞亚群：Th 1细胞，驱动细胞介导的免疫应答，参与组织损伤和细胞内寄生虫感染; Th 2细胞介导IgE产生，特别参与嗜酸性粒细胞炎症、过敏和蠕虫感染的清除。辅助性T细胞的第三个成员，产生IL-17的CD 4 + T细胞，现在被称为Th 17细胞，最近被描述为一种独特的谱系，与Th 1或Th 2细胞不共享发育途径。Th 17亚群与自身免疫性疾病有关，能够产生IL-17、IL-17 F和IL-21以及其他炎性细胞因子。有趣的是，据报道，Th 1、Th 2和Th 17效应细胞之间不仅存在交叉调节，而且在Th 17和T调节细胞的产生中也存在二分法。因此，Treg和Th 17效应细胞以相互排斥的方式出现，这取决于它们是否在TGF-β或TGF-β加炎性细胞因子如IL-6的存在下被激活。本文就Th 17细胞的发现及其发育和调控的最新进展作一综述。
For more than two decades, immunologists have been using the so-called Th1/Th2 paradigm to explain most of the phenomena related to adaptive immunity. The Th1/Th2 paradigm implied the existence of two different, mutually regulated, CD4+ T helper subsets: Th1 cells, driving cell-mediated immune responses involved in tissue damage and infection against intracellular parasites; and Th2 cells that mediate IgE production and are particularly involved in eosinophilic inflammation, allergy and clearance of helminthic infections. A third member of the T helper set, IL-17-producing CD4+ T cells, now called Th17 cells, was recently described as a distinct lineage that does not share developmental pathways with either Th1 or Th2 cells. The Th17 subset has been linked to autoimmune disorders, being able to produce IL-17, IL-17F and IL-21 among other inflammatory cytokines. Interestingly, it has been reported that there is not only a cross-regulation among Th1, Th2 and Th17 effector cells but there is also a dichotomy in the generation of Th17 and T regulatory cells. Therefore, Treg and Th17 effector cells arise in a mutually exclusive fashion, depending on whether they are activated in the presence of TGF-β or TGF-β plus inflammatory cytokines such as IL-6. This review will address the discovery of the Th17 cells, and recent progress on their development and regulation.
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T-BET的丧失，但不是STAT1阻止了实验性自身免疫性脑脊髓炎的发展。
影响因子：
15.3
作者：
Bettelli, E;Sullivan, B;Szabo, SJ;Sobel, RA;Glimcher, H;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
15.3
作者：
Apostolou, I;von Boehmer, H
通讯作者：
von Boehmer, H
DOI：
10.1084/jem.186.6.867
发表时间：
1997-09-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Das MP;Nicholson LB;Greer JM;Kuchroo VK
通讯作者：
Kuchroo VK
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK