Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice
Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice
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DOI：
10.1016/j.bbr.2007.07.031
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发表时间：
2008-01-10
影响因子：
2.7
通讯作者：
Holmes, Andrew
中科院分区：
文献类型：
--
作者：
Boyce-Rustay, Janel M.;Janos, Alicia L.;Holmes, Andrew
压力和压力相关疾病与酒精滥用和酒精中毒的发生率之间有很强的临床关系，这种关系在某种程度上似乎是遗传的。不同菌株对乙醇（EtOH）的相关行为和应激反应存在显著差异，但对两者之间的相互作用研究较少。本研究评估了长期暴露于游泳应激对三种常见近交系小鼠C57BL/6J、DBA/2J和BALB/cByJ etoh相关行为的影响。在两瓶自由选择测试中建立基线（10%）EtOH自我给药后，小鼠连续14天暴露于每天的游泳压力中，并在压力期间和之后的10天内测量EtOH消耗量占基线的百分比。另一项实验检测了14天的游泳应激对急性注射4 g/kg乙胆碱镇静/催眠作用的敏感性的影响。结果显示，与应激前基线相比，应激可显著降低DBA/2J和BALB/cByJ小鼠的EtOH消耗，但C57BL/6J小鼠无此影响。相比之下，应激增加了三种菌株对EtOH镇静/催眠作用的敏感性。这些发现表明，慢性游泳应激会以一种菌株依赖的方式减少EtOH的自我给药，并且这些影响可能仅限于对EtOH有预先厌恶的菌株。目前的数据还表明，这种应激源对EtOH自我给药的影响与对EtOH镇静/催眠作用的敏感性之间存在分离。总之，应变差异可能在很大程度上是遗传的，以特定行为的方式改变应激源对EtOH效应的影响。Elsevier B.V.出版
There is a strong clinical relationship between stress and stress-related disorders and the incidence of alcohol abuse and alcoholism, and this relationship appears to be partly genetic in origin. There are marked strain differences in ethanol (EtOH)-related behaviors and reactivity to stress, but little investigation of the interaction between the two. The present study assessed the effects of chronic exposure to swim stress on EtOH-related behavior in three common inbred strains of mice, C57BL/6J, DBA/2J and BALB/cByJ. After establishing baseline (10%) EtOH self-administration in a two-bottle free choice test, mice were exposed to daily swim stress for 14 consecutive days and EtOH consumption was measured as a percent of baseline both during stress and for 10 days afterwards. A separate experiment examined the effects of 14 days of swim stress on sensitivity to the sedative/hypnotic effects of an acute injection of 4 g/kg EtOH. Results showed that stress produced a significant decrease in EtOH consumption, relative to pre-stress baseline, in DBA/2J and BALB/cByJ, but not C57BL/6J mice. By contrast, stress increased sensitivity to the sedative/hypnotic effects of EtOH in all three strains. These findings demonstrate that chronic swim stress produces reductions in EtOH self-administration in a strain-dependent manner, and that these effects may be restricted to strains with a pre-existing aversion to EtOH. Present data also demonstrates a dissociation between effects of this stressor on EtOH self-administration and sensitivity to EtOH's sedative/hypnotic effects. In conclusion, strain differences, that are likely in large part genetic in nature, modify the effects of this stressor on EtOH's effects in a behavior-specific manner. Published by Elsevier B.V.