Malaria crystalloids: specialized structures for parasite transmission?
Malaria crystalloids: specialized structures for parasite transmission?
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DOI：
10.1016/j.pt.2010.12.004
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发表时间：
2011-03
影响因子：
9.6
通讯作者：
Carter V
中科院分区：
文献类型：
--
作者：
Dessens JT;Saeed S;Tremp AZ;Carter V
疟原虫具有许多独特的亚细胞结构和细胞器，这些结构和细胞器对于疟原虫在脊椎动物宿主和蚊子载体中成功完成复杂的生命周期至关重要。其中包括晶体：一种瞬时结构，其存在仅限于蚊子特有的卵母细胞和寄生虫的年轻卵囊阶段。在首次被描述近50年后，这种晶体重新成为人们关注的焦点，最近的发现指出，这种晶体在蛋白质运输和孢子体传播中起着重要作用，可以作为控制疟疾传播的新靶点。
Malaria parasites possess many unique subcellular structures and organelles that are essential for the successful completion of the complex life cycle of Plasmodium in the vertebrate host and mosquito vector. Among these are the crystalloids: transient structures whose presence is restricted to the mosquito-specific ookinete and young oocyst stages of the parasite. Nearly five decades after they were first described, the crystalloids are back in the spotlight, with recent discoveries pointing to an important role in protein trafficking and sporozoite transmission that could be exploited as new targets for control of malaria transmission.