Sex-specific incident dementia in patients with central nervous system trauma.
Sex-specific incident dementia in patients with central nervous system trauma.
复制标题
中枢神经系统创伤患者的性别特异性痴呆。
DOI：
10.1016/j.dadm.2019.03.003
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Colantonio,Angela
中科院分区：
文献类型：
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作者：
Mollayeva,Tatyana;Hurst,Mackenzie;Escobar,Michael;Colantonio,Angela
前言尽管有证据表明中枢神经系统(CNS)创伤，包括创伤性脑损伤和脊髓损伤，可以导致持续性的神经认知功能障碍，但目前尚不清楚创伤相关变量是否独立于其他已知危险因素与痴呆事件相关。所有创伤相关变量被检验为性别特定的COX回归模型中的预测因素，并控制了其他已知的危险因素。结果在中位数52个月的随访中，712,708名患者中有32,834人(4.6%)发展为痴呆。创伤性脑损伤严重程度和脊髓损伤与年龄相互作用影响痴呆的发病；在所有其他因素相同的情况下，女性比男性更早患痴呆症的风险更大。讨论按性别对中枢神经系统创伤患者进行风险分层对于识别最有可能发展为痴呆症的人以及了解病程和调整因素至关重要。
IntroductionDespite evidence that central nervous system (CNS) trauma, including traumatic brain injury and spinal cord injury, can cause sustained neurocognitive impairment, it remains unclear whether trauma-related variables are associated with incident dementia independently of other known risk factors.MethodsAll adults without dementia entering the health-care system with diagnoses of CNS trauma were examined for occurrence of dementia. All trauma-related variables were examined as predictors in sex-specific Cox regression models, controlling for other known risk factors.ResultsOver a median follow-up of 52 months, 32,834 of 712,708 patients (4.6%) developed dementia. Traumatic brain injury severity and spinal cord injury interacted with age to influence dementia onset; women were at a greater risk of developing dementia earlier than men, all other factors being equal.DiscussionRisk stratification of patients with CNS trauma by sex is vital in identifying those most likely to develop dementia and in understanding the course and modifying factors.