Hospital personnel who handle anticancer drugs may face risks.
Hospital personnel who handle anticancer drugs may face risks.
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处理抗癌药物的医院工作人员可能面临风险。
DOI：
10.1001/jama.1982.03320260003001
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
C. Macek
中科院分区：
文献类型：
--
作者：
C. Macek
虽然许多抗肿瘤药物也被证明是致癌物，但它们的治疗益处通常远远超过对癌症患者的潜在风险。但最近的一项研究表明，对另一个接触化疗药物的人群--准备化疗药物的医院工作人员--存在不合理的危险。Jeffrey C.休斯顿得克萨斯大学公共卫生学院的泰斯博士在一个由美国医学会赞助的国际癌症研讨会上介绍了这项研究的结果。D.休斯顿的安德森医院和肿瘤研究所。泰斯和他的同事们检查了9个M. D.安德森药剂师在艾姆斯试验中的致突变潜力，该试验评估物质诱导细菌回复突变体（突变体）的能力。艾姆斯试验的异常结果通常被认为是该物质致癌性的指示，但该试验的有效性仍有争议。虽然在这些因素之间存在高度的相关性，
Although many antineoplastic drugs also are documented carcinogens, their therapeutic benefits usually far outweigh the potential risks to patients with cancer. But a recent study demonstrates that an unjustified hazard exists for another population exposed to chemotherapeutic agents—the hospital personnel who prepare them. Jeffrey C. Theiss, PhD, of the University of Texas School of Public Health in Houston, presented the results of the study at an international colloquium on cancer sponsored by the M. D. Anderson Hospital and Tumor Institute in Houston. Theiss and his colleagues examined urine samples of nine M. D. Anderson pharmacists for their mutagenic potential in the Ames test, which assesses the ability of a substance to induce revertants (mutants) in bacteria. Abnormal results in the Ames test are often taken as an indication of the substance's carcinogenicity, but the validity of the test is still controversial. Although a high degree of correlation exists between the