A new mouse TCR V gamma gene that shows remarkable evolutionary conservation.
A new mouse TCR V gamma gene that shows remarkable evolutionary conservation.
复制标题
一种新的小鼠 TCR V 伽马基因，显示出显着的进化保守性。
DOI：
10.1002/j.1460-2075.1987.tb02455.x
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Karjalainen
中科院分区：
文献类型：
--
作者：
Jukka Pelkonen;Andre Traunecker;Klaus;Karjalainen
We have identified a new mouse T‐cell receptor V gamma gene segment, V gamma 4.4, which frequently undergoes rearrangements in AKR thymomas, and at a lower frequency in fetal thymocytes. V gamma 4.4 is the fourth and the most 5′ V gene segment in the gamma 4 cluster, being 7.3 kb from V gamma 4.3. Surprisingly, V gamma 4.4 is more homologous to eight human V gamma genes than to the other mouse V gamma genes. It has only a 38% nucleotide and 21% amino acid sequence homology to the most homologous mouse V gamma gene (V gamma 4.1), whereas these homologies to the human V gamma 8 gene are as high as 68% and 48% respectively.
