Changes in the Structure and Cell Composition of Human Carinal Lymph Nodes during Aging
Changes in the Structure and Cell Composition of Human Carinal Lymph Nodes during Aging
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DOI：
10.1007/s10517-018-4246-z
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发表时间：
2018-09-01
影响因子：
0.7
通讯作者：
Mnikhovich, M. V.
中科院分区：
文献类型：
--
作者：
Erofeeva, L. M.;Mnikhovich, M. V.
在隆突淋巴结的结构和细胞组成的变化进行了研究，在人类老化。随着年龄的增长，结节实质被纤维结缔组织替代。髓质物质明显优于皮质物质。皮质内淋巴结较小，无光亮中心;成熟CD 20（+）B细胞浓度较高;皮质旁区破碎且变薄，不含CD 4（+）T辅助细胞。Ki-67（+）细胞在淋巴结的所有结构成分中均不存在，反映淋巴细胞生成功能衰竭，这是由结缔组织取代微环境的网状组织以及调节细胞和体液免疫的CD 4（+）T细胞的缺失决定的。作为生物过滤器的窦系统中的网状间质的崩解损害了淋巴净化的功能。
Changes in the structure and cell composition of carinal lymph nodes were studied in humans during aging. Replacement of node parenchyma with fibrous connective tissue progressing with age was demonstrated. The medullary matter significantly prevailed over the cortical substance. The lymph nodes in the cortical substance were small and had no light centers; the concentration of mature CD20(+) B cells was high; the paracortical area was fragmented and thinned and contained no CD4(+) T helpers. Ki-67(+) cells were absent in all structural components of the lymph nodes reflecting exhaustion of lymphopoietic function, which was determined by the replacement of the reticular tissue of the microenvironment with the connective tissue and by the absence of CD4(+) T cells regulating cellular and humoral immunity. The disintegration of the reticular stroma in the sinus system that acts as a biological filter impairs the function of lymph purification.