Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways
复制标题
DOI：
10.1038/nm1375
复制
发表时间：
2006-03-01
期刊：
影响因子：
82.9
通讯作者：
Larsen, CP
中科院分区：
文献类型：
--
作者：
Cardona, K;Korbutt, GS;Larsen, CP
我们评估了新生猪胰岛在胰腺切除的恒河猴体内植入并恢复血糖控制的能力。尽管移植到未接受免疫抑制的恒河猴体内的猪胰岛会因符合细胞排斥的过程而迅速被排斥，但接受CD28 - CD154共刺激阻断方案治疗的受者实现了持续的胰岛素不依赖（中位生存期>140天），且没有猪内源性逆转录病毒传播的迹象。因此，新生猪胰岛为临床胰岛移植中关键的供体供应问题提供了一个有前景的解决方案。
We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence ( median survival, > 140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.