Jekyll-Hyde neurotrophins:: the story of proNGF
Jekyll-Hyde neurotrophins:: the story of proNGF
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DOI：
10.1016/s0166-2236(02)02169-0
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发表时间：
2002-06-01
影响因子：
15.9
通讯作者：
Ibáñez, CF
中科院分区：
文献类型：
--
作者：
Ibáñez, CF
神经营养因子通过结合两类细胞表面受体促进神经元存活和分化：Trk家族受体酪氨酸激酶的成员和肿瘤坏死因子受体超家族的成员p75（NTR）。未加工的前神经营养素肽既是p75 NTR的优先高亲和力配体（对trkA具有最小亲和力）又是p75（NTR）介导的神经元细胞死亡的有效诱导剂的发现可能改变我们对神经营养素生理学的理解和我们操纵其信号传导途径的能力。
Neurotrophins promote neuronal survival and differentiation by binding to two classes of cell surface receptors: members of the Trk-family receptor tyrosine kinases and p75(NTR), a member of the tumor necrosis factor receptor superfamily. The discoveries that the unprocessed proneurotrophin peptide Is both a preferential high-affinity ligand for p75NTR (with minimal affinity for trkA) and a potent inducer of p75(NTR)-mediated neuronal cell death are likely to change our understanding of neurotrophin physiology and our ability to manipulate their signaling pathways.