Phylogenetic concordance analysis shows an emerging pathogen is novel and endemic.
Phylogenetic concordance analysis shows an emerging pathogen is novel and endemic.
复制标题
系统发育一致性分析表明，一种新出现的病原体是新型且流行的。
作者：
Andrew Storfer;M. Alfaro;B. Ridenhour;J. Jancovich;S. G. Mech;M. Parris;J. Collins
区分病原体是新的还是地方性的对于控制新出现的传染病至关重要，这对野生动物和人类健康构成了越来越大的威胁。为了检验地方病与新型病原体假说，我们提出了一个独特的分析种内宿主病原体系统发育一致性的虎蝾螈和一个新兴的Ranavirus整个北美西部。宿主和病毒基因树存在显著的不一致性，表明病原体新奇。然而，不一致性可能是由于病毒的感染蝾螈的人类运动的介绍。当排除人类相关病毒的引入时，宿主和病毒基因树是相同的，强烈支持共同进化和特有性。一项实验室实验表明，一种引进的病毒株比地方毒株毒力明显更强，这可能是由于人为选择了高毒力。因此，我们的种内系统发育一致性的分析表明，人类引入的病毒是潜在的树不一致的机制，并可能通过人工选择疾病的出现。
Distinguishing whether pathogens are novel or endemic is critical for controlling emerging infectious diseases, an increasing threat to wildlife and human health. To test the endemic vs. novel pathogen hypothesis, we present a unique analysis of intraspecific host-pathogen phylogenetic concordance of tiger salamanders and an emerging Ranavirus throughout Western North America. There is significant non-concordance of host and virus gene trees, suggesting pathogen novelty. However, non-concordance has likely resulted from virus introductions by human movement of infected salamanders. When human-associated viral introductions are excluded, host and virus gene trees are identical, strongly supporting coevolution and endemism. A laboratory experiment showed an introduced virus strain is significantly more virulent than endemic strains, likely due to artificial selection for high virulence. Thus, our analysis of intraspecific phylogenetic concordance revealed that human introduction of viruses is the mechanism underlying tree non-concordance and possibly disease emergence via artificial selection.
测试 Dicamptodon copei 和 Dicamptodon aterrimus（有尾目：Dicamptodontidae）的物种形成时间假设。
DOI：
10.1016/j.ympev.2004.12.001
发表时间：
2005
期刊：
Molecular phylogenetics and evolution.
影响因子：
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作者：
Steele,CraigA;Carstens,BryanC;Storfer,Andrew;Sullivan,Jack
通讯作者：
Sullivan,Jack