Body mass index, abdominal adiposity, obesity, and cardiovascular reactions to psychological stress in a large community sample
Body mass index, abdominal adiposity, obesity, and cardiovascular reactions to psychological stress in a large community sample
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DOI：
10.1097/psy.0b013e31817b9382
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发表时间：
2008-07-01
影响因子：
3.3
通讯作者：
Der, Geoff
中科院分区：
文献类型：
--
作者：
Carroll, Douglas;Phillips, Anna C.;Der, Geoff
目的：在一个大的社区样本中，以横断面和前瞻性的方式研究肥胖与急性心理应激心血管反应程度之间的关系。方法：对1647名成年人在安静状态和短暂时间压力心算应激时的血压和心率（HR）进行测量。在同一时期和5年后测量身高、体重、腰围和臀围，计算体重指数（BMI）和腰臀比。肥胖定义为体重指数>= 30 kg/m2。结果如下：与预期相反，从横断面分析中得出的最可靠和一致的结果是肥胖和HR反应性的所有三个指标之间的负相关;那些BMI和腰臀比较大的人和那些被归类为肥胖的人对压力的HR反应较小。在前瞻性分析中，高HR反应性与随后5年内肥胖的可能性降低相关。结论：我们的分析表明，这是低，而不是高，HR反应性与肥胖有关。低HR反应性，可能是反映了交感神经系统对挑战的反应普遍迟钝，可能是发展肥胖的风险标志。
Objective: To examine the association between adiposity and the magnitude of cardiovascular reactions to acute psychological stress cross-sectionally and prospectively in a large community sample. Methods: Blood pressure and heart rate (HR) were measured at rest and in response to a brief time-pressured mental arithmetic stress in 1647 adults. At the same session and 5 years later, height, weight, waist and hip circumference were measured and body mass index (BMI) and waist-hip ratio were computed. Obesity was defined as a body mass index of >= 30 kg/m(2). Results: Contrary to expectations, the most robust and consistent results to emerge from cross-sectional analyses were negative associations between all three measures of adiposity and HR reactivity; those with greater BMI and waist-hip ratios and those categorized as obese displayed smaller HR reactions to stress. In prospective analyses, high HR reactivity was associated with a reduced likelihood of becoming obese in the subsequent 5 years. Conclusions: Our analyses suggest that it is low, not high, HR reactivity that is related to adiposity. Low HR reactivity, probably by reflecting generally blunted sympathetic nervous system reactions to challenge, may be a risk marker for developing obesity.