Severe bone disease and low bone mineral density after juvenile renal failure
Severe bone disease and low bone mineral density after juvenile renal failure
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DOI：
10.1046/j.1523-1755.2003.00727.x
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发表时间：
2003-01-01
影响因子：
19.6
通讯作者：
Dekker, FW
中科院分区：
文献类型：
--
作者：
Groothoff, JW;Offringa, M;Dekker, FW
背景关于青少年终末期肾病（ESRD）对骨完整性的晚期影响知之甚少。为了确定青少年ESRD患者代谢性骨病和骨密度（BMD）的临床表现，我们进行了一项长期结局研究。一个队列是由1972年至1992年期间年龄0至14岁、1979年之前出生的所有荷兰ESRD患者组成的。通过回顾病历、当前病史、体格检查和腰椎和股骨颈双能X线吸收测定法（DEXA）收集数据。在249名患者中检索到247名患者的临床信息。在所有这些患者中，61.4%有严重的生长迟缓（
Background. Little is known about the late effects of juvenile end-stage renal disease (ESRD) on bone integrity. To establish clinical manifestations of metabolic bone disease and bone mineral density (BMD) in young adult patients with juvenile ESRD, we performed a long-term outcome study.Methods. A cohort was formed of all Dutch patients with onset of ESRD between 1972 and 1992 at age 0 to 14 years, born before 1979. Data were collected by review of medical charts, current history, physical examination, and performing dual energy x-ray absorptiometry (DEXA) of the lumbar spine and the femoral neck.Results. Clinical information was retrieved in 247 out of 249 patients. Of all of these patients, 61.4% had severe growth retardation (