Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study
Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study
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DOI：
10.1016/j.clnu.2017.08.006
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发表时间：
2018-10-01
影响因子：
6.3
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Kokubo, Yoshihiro;Saito, Isao;Tsugane, Shoichiro
背景与目的：膳食镁摄入量与中风和冠心病（CHD）发病率之间的关系在亚洲并不一致，也没有确定。我们的目的是确定日本人群中膳食镁摄入量与中风和冠心病风险之间的关系。受试者/方法：我们在基线时通过问卷调查研究了85,293名日本受试者（1995年和1998年分别为队列I和队列II，年龄45-74岁，无心血管疾病或癌症）。受试者分别在第1组和第2组被跟踪至2009年底和2010年底。膳食镁的摄入量是通过一份自我管理的138项食物频率问卷来估计的。结果：经过1305738人年的随访，记录了4110例中风和1283例冠心病。与男性和女性最低的五分位数相比，膳食镁摄入量第四和第五分位数的冠心病多变量校正风险比（hr， 95%可信区间，95% ci）分别为0.70（0.50-0.99）和0.66 (0.44-0.97)(P为趋势= 0.036)，女性膳食镁摄入量第三分位数为0.61 (0.39-0.96)（P为趋势= 0.241）。我们观察到膳食镁摄入量较高的男性或女性发生卒中的风险没有降低。结论：日本男性较高的膳食镁摄入量与冠心病风险降低有关。(C) 2017爱思唯尔有限公司和欧洲临床营养与代谢学会。版权所有。
Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population.Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45-74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire.Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50-0.99) and 0.66 (0.44-0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39-0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes.Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.