Neurogenesis in Stroke Recovery
Neurogenesis in Stroke Recovery
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DOI：
10.1007/s12975-016-0460-z
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发表时间：
2017-02-01
影响因子：
6.9
通讯作者：
Park, Hyun-Hee
中科院分区：
文献类型：
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作者：
Koh, Seong-Ho;Park, Hyun-Hee
中风是由脑部血流受限引起的，是全世界发病率和死亡率的最重要原因之一。中风被分为缺血性，由于缺乏血液流动，或出血性，由于出血。由于87%的中风被归类为缺血性中风，因此这种类型将是本综述的主要焦点。除了溶栓治疗外，目前还没有确定的治疗方法来减少缺血性中风引起的神经功能障碍。因此，有必要开发新的治疗策略来改善缺血性脑卒中后的神经功能。近年来，对缺血性脑卒中后增强神经发生的治疗方法进行了研究。然而，这些方法并没有导致成功的临床结果。本文综述了脑卒中的病理生理学、脑卒中后的神经发生，以及如何在现有文献的基础上刺激这些过程。最后，正在进行的临床试验，以改善中风后的神经功能，通过加强神经发生讨论在这篇综述。
Stroke, resulting from limited blood flow to the brain, is one of the most important causes of morbidity and mortality worldwide. Stroke is classified as ischemic, due to lack of blood flow, or hemorrhagic, due to bleeding. Because 87 % of strokes are classified as ischemic, this type will be the predominant focus of this review. Except for thrombolytic therapy, there is no established treatment to reduce the neurological deficits caused by ischemic stroke. Therefore, it is necessary to develop new therapeutic strategies designed to improve neurological functions after ischemic stroke. Recently, therapies to enhance neurogenesis after ischemic stroke have been investigated. However, these approaches have not led to successful clinical outcomes. This review addresses the pathophysiology of stroke, neurogenesis after stroke, and how to stimulate these processes based on the current literature. Finally, ongoing clinical trials to improve neurological functions after stroke by enhancing neurogenesis are discussed in this review.