Inhibition of corneal epithelial cell migration by cadmium and mercury.
Inhibition of corneal epithelial cell migration by cadmium and mercury.
复制标题
镉和汞抑制角膜上皮细胞迁移。
DOI：
10.1007/bf01691942
复制
发表时间：
1991
影响因子：
2.7
通讯作者：
Osgood,TB
中科院分区：
文献类型：
--
作者：
Ubels,JL;Osgood,TB
In a previous comparative study of corneal healing in fish, the authors observed that corneal epithelial healing occurs very rapidly in vivo in the marine teleost Myoxocephalus octodecimspinosus (longhorn sculpin) with a 6-mm diameter wound on the mammalian cornea. This rapid healing which permits prompt restoration of the epithelial barrier is apparently an adaptation to the large ionic and osmotic gradients between the environment and the intraocular fluids of the fish. These observations suggested that epithelial healing in the sculpin cornea might be useful model in aquatic biomedical toxicology if an in vitro method for measurement of healing rates could be developed. In this report the authors demonstrate that sculpin eyes maintained in short-term organ culture have a rapid corneal epithelial healing response and that this model can be used to demonstrate the toxic effects of heavy metals on epithelial cell migration.
