Modulation of spinal neuronal excitability by spinal direct currents and locomotion after spinal cord injury
Modulation of spinal neuronal excitability by spinal direct currents and locomotion after spinal cord injury
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DOI：
10.1016/j.clinph.2012.11.021
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发表时间：
2013-06-01
影响因子：
4.7
通讯作者：
Bolliger, M.
中科院分区：
文献类型：
--
作者：
Hubli, M.;Dietz, V.;Bolliger, M.
目的：严重脊髓损伤（SCI）后脊髓神经元功能受损，可以通过分析脊髓反射（SR）行为来评估。我们应用经皮脊髓直流电刺激（tsDCS）和自发活动，以确定是否可以调制运动完全SCI.Method后，脊髓神经元环路的兴奋性运动的基础上：SR诱发的胫神经的非伤害性电刺激。SR行为进行了评估之前，之后立即，和20分钟后，四种不同的干预（阳极，阴极，假tsDCS，或运动）在受试者与运动完全sciandhealthconstituents.Results：SR幅度在SCI受试者增加后，阳极tsDCS的84%（p < 0.05）。阴极，假tsDCS和运动SR振幅没有影响。结论：脊髓损伤后，阳极tsDCS可调节脊髓神经元环路，意义：这种新的、无创性的方法可作为脊髓神经元环路兴奋的工具。如果在训练方法中重复应用，阳极tsDCS可能会防止严重受影响的SCI受试者脊髓反射功能的不良改变，即，脊髓神经元功能障碍的表现，发生在脊髓损伤水平以下。(C)2013年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Spinal neuronal function is impaired after a severe spinal cord injury (SCI) and can be assessed by the analysis of spinal reflex (SR) behavior. We applied transcutaneous spinal direct current stimulation (tsDCS) and locomotor activity, to determine whether the excitability of spinal neuronal circuitries underlying locomotion can be modulated after motor complete SCI.Method: SRs were evoked by non-noxious electrical stimulation of the tibial nerve. SR behavior was assessed before, immediately after, and 20 min after four different interventions (anodal, cathodal, sham tsDCS, or locomotion) in subjects with motor complete SCI and healthy subjects.Results: SR amplitudes in SCI subjects were increased after anodal tsDCS by 84% (p < 0.05). Cathodal, sham tsDCS and locomotion had no influence on SR amplitudes. In addition, reflex threshold was lower after anodal tsDCS and locomotion in SCI subjects (p < 0.05).Conclusion: Anodal tsDCS is able to modulate spinal neuronal circuitries after SCI.Significance: This novel, noninvasive approach might be used as a tool to excite spinal neuronal circuitries. If applied repetitively within a training approach, anodal tsDCS might prevent adverse alterations in spinal reflex function in severely affected SCI subjects, i.e., a manifestation of a spinal neuronal dysfunction taking part below the level of a spinal lesion. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.