Functional Integration Changes in Regional Brain Glucose Metabolism from Childhood to Adulthood
Functional Integration Changes in Regional Brain Glucose Metabolism from Childhood to Adulthood
复制标题
DOI：
10.1002/hbm.23223
复制
发表时间：
2016-08-01
影响因子：
4.8
通讯作者：
De Tiege, Xavier
中科院分区：
文献类型：
--
作者：
Trotta, Nicola;Archambaud, Frederique;De Tiege, Xavier
本研究的目的是探讨从儿童到成年（6-50岁）静息态神经代谢连接的年龄相关变化。54名健康成人受试者和23名假健康儿童在休息时接受[F-18]-氟脱氧葡萄糖正电子发射断层扫描。使用统计参数映射（SPM 8），首先使用年龄和年龄平方作为相关协变量，以确定整个大脑葡萄糖代谢区域分布的线性和非线性年龄效应。然后，通过选择感兴趣的体素（VOI）的区域内显示显着的年龄相关的代谢变化，心理生理相互作用（PPI）的分析被用来寻找年龄引起的变化的贡献VOI的代谢活动在其他脑区。在双侧前额叶皮质（DMPFC/ACC）、小脑小叶和丘脑-海马区发现了区域葡萄糖代谢的显著线性或非线性年龄相关变化。发现丘脑、海马和小脑区域对DMPFC/ACC代谢活性的贡献以及海马对前SMA和右IFG代谢活性的贡献减少。增加被发现在贡献的右侧海马岛叶皮质和小脑小叶IX的上级顶叶皮质代谢活动。本研究证明了内侧前额叶、丘脑、近中颞叶和小脑区域葡萄糖代谢的显著线性或非线性年龄相关变化，与涉及额-丘脑、额-海马和额-小脑网络的神经代谢连接的显著改变相关。这些功能性脑整合的变化可能代表了对感觉、运动和高级认知功能网络的年龄依赖性影响的代谢相关性。(C)2016Wiley Periodicals，Inc.
The aim of this studywas to investigate the age-related changes in resting-state neurometabolic connectivity from childhood to adulthood (6-50 years old). Fifty-four healthy adult subjects and twenty-three pseudo-healthy children underwent [F-18]-fluorodeoxyglucose positron emission tomography at rest. Using statistical parametric mapping (SPM8), age and age squared were first used as covariate of interest to identify linear and non-linear age effects on the regional distribution of glucose metabolism throughout the brain. Then, by selecting voxels of interest (VOI) within the regions showing significant age-related metabolic changes, a psychophysiological interaction (PPI) analysis was used to search for age-induced changes in the contribution of VOIs to the metabolic activity in other brain areas. Significant linear or non-linear age-related changes in regional glucose metabolism were found in prefrontal cortices (DMPFC/ACC), cerebellar lobules, and thalamo-hippocampal areas bilaterally. Decreases were found in the contribution of thalamic, hippocampal, and cerebellar regions to DMPFC/ACC metabolic activity as well as in the contribution of hippocampi to preSMA and right IFGmetabolic activities. Increases were found in the contribution of the right hippocampus to insular cortex and of the cerebellar lobule IX to superior parietal cortex metabolic activities. This study evidences significant linear or non-linear age-related changes in regional glucose metabolism ofmesial prefrontal, thalamic, mesiotemporal, and cerebellar areas, associated with significant modifications in neurometabolic connectivity involving fronto-thalamic, fronto-hippocampal, and fronto-cerebellar networks. These changes in functional brain integration likely represent a metabolic correlate of age-dependent effects on sensory, motor, and high-level cognitive functional networks. (C) 2016Wiley Periodicals, Inc.