Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging.
Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging.
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DOI：
10.1007/s12350-010-9268-5
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发表时间：
2010-12
影响因子：
2.4
通讯作者：
Hofstra, Leonard
中科院分区：
文献类型：
--
作者：
Verjans, Johan;Wolters, Sander;Laufer, Ward;Schellings, Mark;Lax, Michelle;Lovhaug, Dagfinn;Boersma, Hendrikus;Kemerink, Gerrit;Schalla, Simon;Gordon, Paul;Teule, Jaap;Narula, Jagat;Hofstra, Leonard
采用锝-99m标记RGD成像肽（RIP）评估心肌梗死（MI）后间质改变无创成像的临床可行性。在实验研究中，RIP已被证明靶向与胶原生成肌成纤维细胞（MFB）相关的整合素。10例患者在心肌梗死后的第一周内进行了心肌灌注成像（MPI）。在心肌梗死后的3周和8周，静脉给予RIP，并获取SPECT图像进行间质成像。将RIP成像与初始MPI和MI后1年晚期钆增强（LGE）心脏磁共振（CMR）成像定义的瘢痕形成程度进行比较。10例患者中有7例在3周和8周时均观察到RIP摄取。虽然RIP摄取与灌注缺损区域相对应，但它通常在不同程度上延伸到梗死区以外；7例患者中有2例示踪剂在整个心肌中摄取。在所有阳性病例中，RIP摄取与LGE-CMR成像1年时观察到的疤痕程度相似。本研究表明，心肌梗死后早期基于rgd的成像可以预测瘢痕形成的最终程度，该程度通常超过最初的MPI缺陷，但在随后进行的CMR成像中与LGE共定位。
The clinical feasibility of noninvasive imaging of interstitial alterations after myocardial infarction (MI) was assessed using a technetium-99m-labeled RGD imaging peptide (RIP). In experimental studies, RIP has been shown to target integrins associated with collagen-producing myofibroblasts (MFB). Ten patients underwent myocardial perfusion imaging (MPI) within the first week after MI. At 3 and 8 weeks after MI, RIP was administered intravenously and SPECT images acquired for interstitial imaging. RIP imaging was compared to initial MPI and to the extent of scar formation defined by late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR) imaging 1 year after MI. RIP uptake was observed in 7 of the 10 patients at both 3 and 8 weeks. Although, RIP uptake corresponded to areas of perfusion defects, it usually extended beyond the infarct zone to a variable extent; 2 of 7 patients showed tracer uptake throughout myocardium. In all positive cases, RIP uptake was similar to the extent of scar observed at 1 year by LGE-CMR imaging. This study demonstrates that RGD-based imaging early after MI may predict the eventual extent of scar formation, which often exceeds initial MPI deficit but colocalizes with LGE in CMR imaging performed subsequently.
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影响因子：
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通讯作者：
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影响因子：
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Verjans, Johan W. H.;Lovhaug, Dagfinn;Narula, Jagat
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Schwaiger M
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6
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Park, S;Choi, BW;Cho, SY
通讯作者：
Cho, SY