HLA-G DELETION POLYMORPHISM AND PREECLAMPSIA ECLAMPSIA
HLA-G DELETION POLYMORPHISM AND PREECLAMPSIA ECLAMPSIA
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DOI：
10.1111/j.1471-0528.1995.tb11427.x
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发表时间：
1995-09-01
期刊：
影响因子：
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通讯作者：
TRUDINGER, BJ
中科院分区：
文献类型：
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作者：
HUMPHREY, KE;HARRISON, GA;TRUDINGER, BJ
目的探讨先兆子痫家系和一般人群的HLA-G缺失多态性。设计先兆子痫/子痫患者和对照组的HLA-G基因型的群体关联研究。设置分析在麦考瑞大学生物科学学院进行。患者来自墨尔本皇家妇女医院，对照来自 Westmead 医院和悉尼麦考瑞大学。 受试者 196 名受试者，其中 29 名先兆子痫/子痫 (PE/E) 患者、13 名 PE/E 妊娠所生者、46 名 PE/E 患者的血亲、21 名 PE/E 患者的丈夫、25 名首次怀孕时血压正常的女性、15 名血压正常女性的丈夫麦考瑞大学 47 名教职员工和学生首次怀孕。结果 七组检查的基因型和基因频率没有显着差异。结论 先兆子痫的易感性或先兆子痫出生与 HLA-G 基因型之间没有可检测到的关系。
Objective To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population.Design A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups.Setting Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney.Subjects One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University.Results Genotypic and gene frequencies were not significantly different in the seven groups examined.Conclusion There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.