A luteolytic action of prolactin in hypophysectomized rats.
A luteolytic action of prolactin in hypophysectomized rats.
复制标题
垂体切除大鼠中催乳素的黄体分解作用。
DOI：
10.1210/endo-79-2-268
复制
发表时间：
1966
期刊：
影响因子：
4.8
通讯作者：
C. Sawyer
中科院分区：
文献类型：
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作者：
P. Malven;C. Sawyer
成年雌性大鼠去垂体术后数周开始注射催乳素，显着加速黄体形态退化，显着减轻卵巢重量。这种黄体溶解首先是在用FSH和LH预处理的大鼠身上观察到的，剂量后来被证明不足以诱导排卵。随后的实验清楚地表明，促性腺激素的预处理不会以任何方式加强催乳素诱导的黄体溶解。无论是用促性腺激素预处理的动物还是未用促性腺激素预处理的动物，诱导黄体溶解的程度都取决于催乳素的剂量。催乳素诱导黄体溶解的最小剂量为0.25IU/d，连续给药13天。长期应用促黄体生成素或促黄体生成素治疗不会导致黄体溶解。组织学上，催乳素诱导的黄体溶解以小体周围结缔组织成分的侵袭为特征。在最近的一次会议上，第一个可观察到的效应是…
Prolactin injections begun several weeks after hypophysectomy in adult female rats markedly hastened the morphological regression of corpora lutea and significantly reduced ovarian weights. This luteolysis was first observed in rats pretreated with FSH and LH in dosages which were later proven insufficient for inducing ovulation. Subsequent experiments clearly demonstrated that pretreatment with the gonadotrophins did not in any way potentiate the luteolysis induced by prolactin. The degree of induced luteolysis was dependent on the prolactin dosage both in animals pretreated with gonadotrophins and in those receiving no pretreatment. The minimal dosage of prolactin found to induce significant luteolysis was 0.25 IU/day administered for 13 days. Prolonged treatment with FSH or LH did not result in luteolysis. Histologically the prolactin-induced luteolysis was characterized by an invasion of connective tissue elements from the periphery of the corporalutea. The first observable effect in the most recent g...