The value of primate models for studying human immunodeficiency virus pathogenesis
The value of primate models for studying human immunodeficiency virus pathogenesis
复制标题
DOI：
10.1111/j.1600-0684.1996.tb00013.x
复制
发表时间：
1996-06-01
影响因子：
0.7
通讯作者：
Levy, JA
中科院分区：
文献类型：
--
作者：
Levy, JA
对人类免疫缺陷病毒（HIV）感染的研究受到了明显的限制，即只对病毒感染者或接触病毒的人进行研究。涉及传播或发病机制的步骤需要有计划的实验。因此，获得性免疫缺陷综合征（AIDS）动物模型的鉴定有助于评估HIV发病机制的阶段。在目前已知的七个慢病毒亚属中，有两个与HIV具有T细胞嗜性和与疾病相关的宿主中CD4+细胞丢失的特征：猫免疫缺陷病毒（FIV）和猴免疫缺陷病毒（SIV）（表1）。其他动物慢病毒在巨噬细胞中生长最好，它们的感染通常反映了这种细胞类型感染的临床后遗症。本文综述了非人灵长类动物SIV、HIV和SHIV感染的特征，说明了艾滋病动物模型的重要性。
Research on human immunodeficiency virus (HIV) infection is compromised by the obvious limitation in having for study only virus-infected individuals or those exposed to the virus. Steps involved in transmission or pathogenesis require planned experimentation. The identification of animal models of acquired immunodeficiency syndrome (AIDS) has therefore been helpful for evaluating phases of HIV pathogenesis. Of the seven subgenera of lentiviruses now recognized, two share the characteristics with HIV of a T cell tropism and the associated loss of CD4+ cells in the host associated with disease: the feline immunodeficiency virus (FIV) and the simian immunodeficiency virus (SIV) (Table 1). The other animal lentiviruses grow best in macrophages and their infection generally reflects clinical sequellae of infection of this cell type. This review addresses those features of SIV, HIV, and SHIV infections of nan-human primates that illustrate the importance of the animal models of AIDS.