An evaluation of the amyloid cascade model using in vivo positron emission tomographic imaging
An evaluation of the amyloid cascade model using in vivo positron emission tomographic imaging
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DOI：
10.1111/psyg.12589
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发表时间：
2020-08
期刊：
影响因子：
2
通讯作者：
F. Yasuno;A. Nakamura;Takashi Kato;K. Iwata;T. Sakurai;Y. Arahata;Y. Washimi;H. Hattori;Kengo Ito
中科院分区：
文献类型：
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作者：
F. Yasuno;A. Nakamura;Takashi Kato;K. Iwata;T. Sakurai;Y. Arahata;Y. Washimi;H. Hattori;Kengo Ito
淀粉样蛋白级联假说假定淀粉样蛋白β（Aβ）的积累是阿尔茨海默病的触发因素，其连续诱导tau蛋白聚集、突触丢失和细胞死亡。大多数实验和临床证据支持这一模型，但现有的数据主要是定性的。在这里，我们测试了淀粉样蛋白级联假说，通过使用体内评价正电子发射断层扫描和磁共振成像。
The amyloid cascade hypothesis posits that the accumulation of amyloid β (Aβ) is the triggering factor for Alzheimer's disease, which consecutively induces aggregation of tau, synaptic loss, and cell death. Most experimental and clinical evidence supports this model, but the available data are largely qualitative. Here, we tested the amyloid cascade hypothesis by using in vivo evaluation of positron emission tomography and magnetic resonance imaging.