Timing and duration of use of GnRH antagonist down-regulation for IVF/ICSI cycles have no impact on oocyte quality or pregnancy outcomes
Timing and duration of use of GnRH antagonist down-regulation for IVF/ICSI cycles have no impact on oocyte quality or pregnancy outcomes
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DOI：
10.1007/s10815-008-9217-2
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发表时间：
2008-05-01
影响因子：
3.1
通讯作者：
Puscheck, Elizabeth E.
中科院分区：
文献类型：
--
作者：
Detti, Laura;Ambler, Dana R.;Puscheck, Elizabeth E.
目的探讨促性腺激素释放激素（GnRH）拮抗剂的使用时间和使用时机对体外受精（IVF）/胞质内单精子注射（ICSI）中卵母细胞质量、着床和妊娠结局的影响。所有患者均接受促性腺激素和促性腺激素释放激素受体拮抗剂促排卵，以下调垂体。结果促性腺激素释放激素拮抗剂的使用时间或开始使用时间与卵母细胞质量或着床和妊娠结局之间无相关性。卵母细胞质量受雌二醇峰值的影响。植入受患者年龄的影响。早期妊娠丢失，子宫内膜厚度受人绒毛膜促性腺激素日影响。持续妊娠是独立的变量evaluated.Conclusions GnRH拮抗剂的使用时间或开始一天没有影响卵母细胞的质量，植入率和妊娠率。我们推测，当拮抗剂开始时，促卵泡激素/促黄体激素剂量增加，可能对我们的发现产生影响。
Purpose To evaluate whether oocyte quality, implantation and pregnancy outcomes in in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI) are related to the duration of gonadotropin-releasing hormone (GnRH)-antagonist use or the timing of its initiation.Methods Retrospective cohort study of 178 conventional IVF/ICSI cycles. All patients underwent ovarian stimulation with gonadotropins and GnRH-antagonist for pituitary down-regulation. Spearman correlations and logistic regression were used for statistical analysis.Results There was no correlation between the duration of use or the timing of initiation of GnRH-antagonist with oocyte quality or implantation and pregnancy outcomes. Oocyte quality was influenced by the peak estradiol. Implantation was influenced by the patient's age. Early pregnancy loss, by the endometrial thickness on human chorionic gonadotropin-day. Ongoing pregnancy was independent from the variables evaluated.Conclusions GnRH-antagonist duration of use or starting day did not influence oocyte quality, implantation rates, and pregnancy rates. We hypothesize that a follicle stimulating hormone/luteinizing hormone dose increase when antagonist was started, may have had an impact on our findings.