Electrospun curcumin-loaded cellulose acetate/polyvinylpyrrolidone fibrous materials with complex architecture and antibacterial activity.
Electrospun curcumin-loaded cellulose acetate/polyvinylpyrrolidone fibrous materials with complex architecture and antibacterial activity.
复制标题
DOI：
10.1016/j.msec.2016.12.086
复制
发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
P. Tsekova;M. Spasova;N. Manolova;N. Markova;Iliya B Rashkov
中科院分区：
文献类型：
--
作者：
P. Tsekova;M. Spasova;N. Manolova;N. Markova;Iliya B Rashkov
以醋酸纤维素（CA）和聚乙烯吡咯烷酮（PVP）为原料，采用一锅法和双喷丝板法制备了姜黄素（Curc）复合纤维材料。采用扫描电子显微镜（SEM）、荧光显微镜、傅里叶变换红外光谱仪（FTIR）、紫外-可见光谱仪（UV-Vis）、差示扫描量热仪（DSC）、水接触角测量仪和微生物测试仪对静电纺丝材料进行了表征。结果表明，在CA和PVP溶液中加入Curc后，溶液的粘度增加，纤维直径增大（约100 nm）。1.5μm）相比，纯CA（约800 nm）和PVP纤维（约500纳米）的波长。PVP的加入提高了纤维的亲水性，加快了Curc的释放。结果表明，含Curc的纤维中Curc以非晶态存在，并对金黄色葡萄球菌（S. aureus)具有良好的抗菌活性。结果表明，由于其复杂的结构，所获得的新型抗菌材料适合于伤口敷料应用，这需要生物活性化合物的不同释放行为。
Novel fibrous materials from cellulose acetate (CA) and polyvinylpyrrolidone (PVP) containing curcumin (Curc) with original design were prepared by one-pot electrospinning or dual spinneret electrospinning. The electrospun materials were characterized by scanning electron microscopy (SEM), fluorescence microscopy, Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV–Vis), differential scanning calorimetry (DSC), water contact angle measurements, and microbiological tests. It was found that the incorporation of Curc into the CA and PVP solutions resulted in an increase of the solution viscosity and obtaining fibers with larger diameters (ca. 1.5 μm) compared to the neat CA (ca. 800 nm) and PVP fibers (ca. 500 nm). The incorporation of PVP resulted in increased hydrophilicity of the fibers and in faster Curc release. Curc was found in the amorphous state in the Curc-containing fibers and these mats exhibited antibacterial activity againstStaphylococcus aureus(S. aureus). The results suggest that, due to their complex architecture, the obtained new antibacterial materials are suitable for wound dressing applications, which necessitate diverse release behaviors of the bioactive compound.