Advances in materials that enable quantitative point-of-care assays
Advances in materials that enable quantitative point-of-care assays
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DOI：
10.1557/mrs.2013.57
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发表时间：
2013-04-01
期刊：
影响因子：
5
通讯作者：
Lewis, Gregory G.
中科院分区：
文献类型：
--
作者：
Phillips, Scott T.;Lewis, Gregory G.
用于在护理点（POC）测定中获得定量测量的传统范例可能不足以用于资源极其有限的环境，例如发展中国家的偏远村庄。在标准的POC定量测定中，必须控制样品体积和测定时间。此外，必须提供热稳定的测定试剂、电源和电子阅读器。将所有这些变量安排在单个测定中会导致系统过于复杂、昂贵并且对于资源极其有限的环境来说是用户密集型的。本概述描述了材料科学各个领域的新方法，这些方法开始重新定义如何实现定量POC测定，重点是使用纸张作为测定平台的方法。这些方法应该在发展中国家产生直接影响，但也可能在各种其他环境中改变定量POC检测，其中有关人类，植物，动物和环境健康的定量信息将帮助个人更好地评估和管理他们的生活。
The traditional paradigm for obtaining a quantitative measurement in point-of-care (POC) assays may not be adequate for extremely resource-limited environments, such as remote villages in the developing world. In standard quantitative POC assays, sample volume and assay time must be controlled. Furthermore, thermally stable assay reagents, a power supply, and an electronic reader must be available. Arranging all of these variables in a single assay results in systems that are too complicated, expensive, and user-intensive for extremely resource-limited environments. This overview describes new approaches in various areas of materials science that are beginning to redefine how quantitative POC assays are achieved, with a focus on approaches that use paper as the platform for the assays. Such approaches should have an immediate impact in the developing world, but also may transform quantitative POC assays in a variety of other settings, where quantitative information about the health of people, plants, animals, and the environment would help individuals better assess and manage their lives.