Risk Factors Associated With Dyspepsia in a Rural Asian Population and Its Impact on Quality of Life
Risk Factors Associated With Dyspepsia in a Rural Asian Population and Its Impact on Quality of Life
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DOI：
10.1038/ajg.2010.26
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发表时间：
2010-04-01
影响因子：
9.8
通讯作者：
Goh, Khean-Lee
中科院分区：
文献类型：
--
作者：
Mahadeva, Sanjiv;Yadav, Hematram;Goh, Khean-Lee
结论：亚洲农村消化不良的流行病学和影响仍不确定。我们的目的是确定在马来西亚农村community.METHODS的流行病学和消化不良的影响，在一个有代表性的农村人口在马来西亚进行了挨家挨户的调查。根据罗马II标准定义消化不良，并使用Euroqol（EQ-5D）工具评估健康相关生活质量（HRQOL）。受访者的平均年龄为40.4 +/- 15.3岁，62.7%为妇女，79.0%为马来族，8.4%受过高等教育，49.7%失业，63.4%居住在村庄式住房中，49.1%每户有8名以上居民。292名（14.6%）成人普遍存在消化不良，与健康对照组相比，他们的平均EQ-5D效用评分较低（0.91 +/- 0.17 vs. 0.97 +/- 0.08，P < 0.0001）。消化不良与女性有关（男性15.8 vs. 12.7%，P = 0.058），中国种族（19.7%对14.2%非华裔）、较高教育水平、中等收入（19.1%中等及13.3%低等），非乡村式房屋（16.3% vs. 13.5%乡村式住宅，P = 0.08），不吸烟者（18.7 vs. 13.7%，P = 0.015），不饮茶者（19.5 vs. 12.3%，P < 0.0001），定期服用镇痛药（27 vs. 12.7%，P < 0.0001），慢性病成人（26.6 vs. 11.1%，P < 0.0001）。Logistic回归分析显示，教育水平较高，即，二次（比值比（OR）2.13，95%置信区间（CI）= 1.15-3.93）和三级（2.70，95% CI = 1.30-5.62）教育、非乡村住房（OR 1.36，95% CI = 1.02-1.80）、规律镇痛（OR 2.22，95% CI = 1.60-3.09）和慢性病（OR 2.83，95% CI = 2.12 ~ 3.77）是消化不良的独立危险因素。相反，经常喝茶（OR 0.59）似乎有一个反比关系。结论：马来西亚农村的消化不良与较低的HRQOL。流行病学风险因素包括较高的社会经济地位，定期服用止痛药和慢性疾病。
OBJECTIVES: The epidemiology and impact of dyspepsia in rural Asia remains uncertain. We aimed to determine the prevalence epidemiology and impact of dyspepsia in a rural Malaysian community.METHODS: A door-to-door survey was conducted in a representative rural population in Malaysia. Dyspepsia was defined according to the Rome II criteria, and health-related quality of life (HRQOL) was assessed using the Euroqol (EQ-5D) instrument.RESULTS: Of 2,260 adults, 2,000 (88.5%) completed the survey. The mean age of respondents was 40.4 +/- 15.3 years, 62.7% were women, 79.0% were ethnic Malays, 8.4% had been educated up to the tertiary level, 49.7% were unemployed, and 63.4% resided in village-type housing with 49.1% having > 8 residents per household. Dyspepsia was prevalent in 292 (14.6%) adults, and they had lower mean EQ-5D utility scores compared with healthy controls (0.91 +/- 0.17 vs. 0.97 +/- 0.08, P < 0.0001). Dyspepsia was found to be associated with female gender (15.8 vs. 12.7% males, P = 0.058), Chinese ethnicity (19.7 vs. 14.2% non-Chinese), higher education levels, medium-range incomes (19.1% medium range vs. 13.3% low range), non-village-type housing (16.3 vs. 13.5% village-type house, P = 0.08), nonsmokers (18.7 vs. 13.7%, P = 0.015), non-tea drinkers (19.5 vs. 12.3%, P < 0.0001), regular analgesia intake (27 vs. 12.7%, P < 0.0001), and adults with chronic illness (26.6 vs. 11.1%, P < 0.0001). Logistic regression analysis showed that higher levels of education, i.e., secondary (odds ratio (OR) 2.13, 95% confidence interval (CI) = 1.15-3.93) and tertiary (2.70, 95% CI = 1.30-5.62) education, non-village housing (OR 1.36, 95% CI = 1.02-1.80), regular analgesia (OR 2.22, 95% CI = 1.60-3.09), and chronic illness (OR 2.83, 95% CI = 2.12 -3.77) were independent risk factors for dyspepsia. Conversely, regular tea drinking (OR 0.59) seemed to have an inverse relationship.CONCLUSIONS: Dyspepsia in rural Malaysians is associated with a lower HRQOL. Epidemiological risk factors include a higher socioeconomic status, regular analgesic consumption, and chronic illness.