Combined lifestyle factors and risk of incident colorectal cancer in a Chinese population.
Combined lifestyle factors and risk of incident colorectal cancer in a Chinese population.
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DOI：
10.1158/1940-6207.capr-12-0384
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Yuan JM
中科院分区：
文献类型：
--
作者：
Odegaard AO;Koh WP;Yuan JM
一系列研究将饮食摄入、饮酒、吸烟、体育活动、体重指数（BMI）以及可能的睡眠模式与结直肠癌风险联系起来。然而，很少有研究探讨这些生活方式因素与结直肠癌发病率的关系，特别是在非西方人群中。建立了上述6个因素的保护性生活方式因素指数，并检查了与结直肠癌风险的关系。本研究是一项前瞻性观察性研究，研究对象为1993-1998年参加新加坡华人健康研究并随访至2007年的新加坡50,466名45-74岁的华人男性和女性。主要结局指标是结直肠癌发病率的标准化率和风险比。每个生活方式因素的保护水平与结肠癌的年龄和性别标准化发病率降低独立相关。当所有的因素组合成一个单一的保护性生活方式因素指数，有一个强烈的，单调下降，结肠癌的发病率与得分增加。相对于指数评分为0-3的参与者，风险比指数评分为4、5、6、7、8、9/10的结肠癌的95%可信区间为0.58（0.35-0.95）、0.56（0.36-0.86）、0.50（0.33-0.76）、0.43（0.28-0.66）、0.39（0.25-0.63）和0.25（0.12-0.54）（趋势P <0.0001）。结果与性别一致。相反，与直肠癌风险无关。在中国男性和女性中，保护性生活方式因素指数得分的增加与结肠癌发病风险的显著降低相关。
A body of research links dietary intake, alcohol consumption, smoking, physical activity, body mass index (BMI), and possibly sleep patterns with colorectal cancer risk. However, little research has examined the association of the combination of these lifestyle factors with incidence of colorectal cancer, especially in non-western populations. A protective lifestyle factor index of these 6 aforementioned factors was created and examined in relation to risk of developing colorectal cancer. This study is a prospective observational study of 50,466 Chinese men and women in Singapore aged 45–74 during enrollment in the Singapore Chinese Health Study in 1993–1998 and followed up through 2007. The main outcome measures were standardized rates and hazard ratios of incident colorectal cancer. The protective levels of each lifestyle factor were independently associated with reduced age- and sex-standardized incidence rates of colon cancer. When all the factors were combined into a single protective lifestyle factor index, there was a strong, monotonic decrease in incidence rate of colon cancer with an increasing score. Relative to participants with an index score of 0–3, the hazard ratios (95% confidence intervals) of colon cancer for an index score of 4, 5, 6, 7, 8, 9/10 were 0.58 (0.35–0.95), 0.56 (0.36–0.86), 0.50 (0.33–0.76), 0.43 (0.28–0.66), 0.39 (0.25–0.63), and 0.25 (0.12–0.54) (P for trend <0.0001). The results were consistent by sex. Conversely, there was no association with rectal cancer risk. An increasing protective lifestyle factor index score is associated with a marked decreased risk of developing colon cancer in Chinese men and women.