Prenatal exposure to bisphenol A impairs sexual differentiation of exploratory behavior and increases depression-like behavior in rats
Prenatal exposure to bisphenol A impairs sexual differentiation of exploratory behavior and increases depression-like behavior in rats
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DOI：
10.1016/j.brainres.2005.11.028
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发表时间：
2006-01-12
期刊：
影响因子：
2.9
通讯作者：
Aou, S
中科院分区：
文献类型：
--
作者：
Fujimoto, T;Kubo, K;Aou, S
围产期暴露于双酚A（BPA，0.1和1 ppm的饮用水应用于母大鼠6周）已被证明会损害探索行为的性分化，但这种破坏作用的确切关键时期仍然未知。在这项研究中，我们检查了产前暴露于BPA（在怀孕的最后一周，在饮用水中施用0.1 ppm的BPA）对情绪和学习行为以及探索行为的影响。估计每日摄入量为15 pg/kg/天，低于美国的参考剂量（RfD）和日本的每日耐受摄入量（TDI）（SO P g/kg/天）。在6 ~ 9周龄的幼年期，对大鼠进行旷场实验、高架十字迷宫实验、被动回避实验和强迫游泳实验。出生前暴露于BPA主要影响雄性大鼠，并消除了旷场试验中的直立行为和强迫游泳试验中的挣扎行为的性别差异。BPA在强迫游泳试验中增加雄性大鼠的不动性。对小鼠的回避学习和高架十字迷宫行为无影响。本研究表明，雄性大鼠在产前最后一周是敏感的BPA，这损害了性分化的饲养和挣扎行为，并促进抑郁样行为。(c)2005 Elsevier B. V.保留所有权利。
Perinatal exposure to bisphenol A (BPA, 0.1 and I ppm in drinking water applied to mother rats for 6 weeks) has been shown to impair the sexual differentiation in exploratory behavior, but the exact critical period of this disrupting effect is still unknown. in this study, we examined the effects of prenatal exposure to BPA (0.1 ppm in drinking water applied dams during the final week of pregnant) on emotional and learning behaviors in addition to exploratory behavior. Estimated daily intake was 15 pg/kg/day, below the reference dose (RfD) in the United States and the daily tolerable intake (TDI) in Japan (SO P g/kg/day). The rats were successively tested in open-field test, elevated plus maze test, passive avoidance test and forced swimming test during development from 6 to 9 weeks of juvenile period. Prenatal exposure to BPA mainly affected male rats and abolished sex differences in rearing behavior in the open-field test and struggling behavior in the forced swimming test. BPA increased the immobility of male rats in the forced swimming test. The avoidance learning and behaviors in the elevated plus maze were not affected. The present study demonstrates that male rats at the final week of prenatal period are sensitive to BPA, which impairs sexual differentiation in rearing and struggling behavior and facilitate depression-like behavior. (c) 2005 Elsevier B.V. All rights reserved.