Intermolecular C-H and Si-H Insertion Reactions with Halodiazoacetates
Intermolecular C-H and Si-H Insertion Reactions with Halodiazoacetates
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DOI：
10.1055/s-0028-1083272
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发表时间：
2009-01-02
影响因子：
2.6
通讯作者：
Hansen, Tore
中科院分区：
文献类型：
--
作者：
Bonge, Hanne Therese;Hansen, Tore
卤代重氮乙酸乙酯与一系列底物在区域选择性Rh(II)催化的C-H和Si-H插入反应中反应，生成α-卤代羰基产物，产率高达82%。卤代重氮乙酸酯是一类新型的重氮化合物，可以进行分子间的卡宾C-H插入反应，从而拓宽了此类反应的合成用途。
Ethyl halodiazoacetates react with a range of substrates in regioselective rhodium(II)-catalysed C-H and Si-H insertion reactions giving alpha-halocarbonyl products in up to 82% yield. The halodiazoacetates are a novel class of diazo compounds that can undergo intermolecular carbenoid C-H insertion reactions, thus broadening the synthetic utility of such reactions.