Juvenile Fibroadenoma with Atypical Epithelial Hyperplasia
Juvenile Fibroadenoma with Atypical Epithelial Hyperplasia
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幼年型纤维腺瘤伴非典型上皮增生
DOI：
10.1097/00000478-198703000-00002
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
P. Peter Rosen
中科院分区：
文献类型：
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作者：
C. Mies;P. Peter Rosen
我们研究了49例纤维腺瘤合并严重的不典型上皮增生，有时提示为原位癌。对于这些主要发生在青春期和年轻女性的病变，推荐使用“幼年纤维腺瘤”(JFA)一词。26例(2%)是通过对1321例连续纤维腺瘤的回顾而获得的，23例是通过会诊获得的。49例患者年龄在10-72岁之间(平均26岁)；50%的患者年龄在21岁以下。这一年龄分布显著低于成人FA患者(p<；0.001)。导管乳头状型、实性型、囊状乳头型和小叶终末型4种不典型上皮细胞增生类型。46例患者仅行手术切除。平均随访时间为8年，中位随访期为7年，28例(57%)患者随访期超过1年(1-19年)。两名患者在诊断JFA时年龄分别为47岁和59岁，随后分别发展为对侧和同侧乳癌；其他患者均保持良好。这种情况下的非典型上皮细胞增殖应保守解释。建议JFA切除后进行长期随访。
We studied 49 patients with fibroadenomas with severe atypical epithelial hyperplasia, sometimes suggestive of in situ carcinoma. The term “juvenile fibroadenoma” (JFA) is recommended for these lesions, which occur mainly in adolescent and young women. Twenty-six cases (2%) were obtained through a review of 1,321 consecutive fibroadenomas and 23 were seen in consultation. The 49 patients ranged in age from 10-72 years (average 26 years); 50% were younger than 21 years. This age distribution was significantly lower than that of patients with adult FA (p<0.001). Four patterns of atypical epithelial hyperplasia were observed: ductal-laciform, ductal-solid, cystic-papillary and lobular-terminal ductal. Forty-six patients were treated by excision only. Eight years was the average follow-up and 7 years the median follow-up for 28 (57%) patients followed for more than a year (range 1-19 years). Two patients, aged 47 and 59 years at the time of diagnosis of JFA, subsequently developed carcinoma in the contralateral and ipsilateral breast, respectively; all others have remained well. Atypical epithelial proliferation in this setting should be interpreted conservatively. Long-term follow-up is recommended after excision of JFA.