Cobalt-catalyzed oxidative isocyanide insertion to amine-based bisnucleophiles: diverse synthesis of substituted 2-aminobenzimidazoles, 2-aminobenzothiazoles, and 2-aminobenzoxazoles.
Cobalt-catalyzed oxidative isocyanide insertion to amine-based bisnucleophiles: diverse synthesis of substituted 2-aminobenzimidazoles, 2-aminobenzothiazoles, and 2-aminobenzoxazoles.
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DOI：
10.1002/chem.201300239
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发表时间：
2013-05
期刊：
影响因子：
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通讯作者：
Tonghao Zhu;Shun‐Yi Wang;Gao Wang;S. Ji
中科院分区：
文献类型：
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作者：
Tonghao Zhu;Shun‐Yi Wang;Gao Wang;S. Ji
钴催化：通过使用乙酸钴（II）催化的异氰化物插入邻-二氨基苯、2-氨基苯乙胺和2-氨基苯酚衍生物的1，4-二氧六环中来合成取代的2-氨基苯并咪唑、2-氨基苯并噻唑和2-氨基苯并恶唑（参见方案）。发现反应有效地进行，通过在单一步骤中形成C-N和C-S（O，N）以高达95%的分离产率得到所需产物。
Cobalt catalysis: Synthesis of substituted 2-aminobenzimidazoles, 2-aminobenzothiazoles, and 2-aminobenzoxazoles was achieved by using cobalt(II) acetate catalyzed isocyanide insertion to o-diaminobenzene, 2-aminobenzenethiol, and 2-aminophenol derivatives in 1,4-dioxane (see scheme). It was found that the reaction proceeded efficiently to give the desired products in up to 95 % isolated yields by C-N and C-S (O, N) formation in a single step.