CHRONIC LOW-LEVEL MATERNAL CARBON-MONOXIDE EXPOSURE AND FETAL GROWTH AND DEVELOPMENT
CHRONIC LOW-LEVEL MATERNAL CARBON-MONOXIDE EXPOSURE AND FETAL GROWTH AND DEVELOPMENT
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DOI：
10.1095/biolreprod19.1.8
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发表时间：
1978-01-01
影响因子：
3.6
通讯作者：
LONGO, LD
中科院分区：
文献类型：
--
作者：
GARVEY, DJ;LONGO, LD
本文研究了孕鼠连续暴露于低浓度CO（30或90 ppm）和低氧（13%O_2）环境中对胎鼠生长发育的影响。虽然没有CO浓度引起的血液学反应，在怀孕的动物，13%的O2暴露引起红细胞压积，红细胞数量和Hb浓度的增加。胎仔的身体生长不受任何CO浓度的影响，但是，在暴露于13%O2的胎仔中，它显着降低。个别器官重量的差异影响90 ppm CO。胎脑湿重增加14%，而肺重量下降24%。90 ppm CO胎仔的脑增大归因于脑蛋白、DNA、去甲肾上腺素和5-羟色胺浓度降低以及干湿重比降低所证明的含水量增加。宫内胎儿受到母体环境中相对较低的CO浓度的影响。
Effects on fetal growth and development of continuous exposure of pregnant rats to low level CO (30 or 90 ppm) and a low O2 atmosphere (13% O2) were investigated. While neither CO concentration induced a hematologic response in the pregnant animals, 13% O2 exposure elicited an increase in hematocrit, the number of erythrocytes and Hb concentration. Fetal body growth was unaffected by either CO concentration; however, it was reduced significantly in fetuses exposed to 13% O2. The individual organ weights were differentially affected by 90 ppm CO. The fetal brain wet weight increased 14%, whereas the lung weight decreased 24%. The brain enlargement in the 90 ppm CO fetuses was attributed to an increased water content as evidenced by decreased concentrations of brain protein, DNA, norepinephrine and serotonin and a reduced dry-wet weight ratio. The fetus in utero was affected by relatively low CO concentrations in the maternal environment.