Synthesis of TDP-3-amino-3,4,6-trideoxy-alpha-D-xylo-hexopyranose--the immediate precursor of TDP-alpha-D-desosamine.
Synthesis of TDP-3-amino-3,4,6-trideoxy-alpha-D-xylo-hexopyranose--the immediate precursor of TDP-alpha-D-desosamine.
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TDP-3-氨基-3,4,6-三脱氧-α-D-木基己吡喃糖的合成——TDP-α-D-去糖胺的直接前体。
DOI：
10.1016/s0960-894x(02)00209-3
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发表时间：
2002
影响因子：
2.7
通讯作者：
Liu,Hung-wen
中科院分区：
文献类型：
--
作者：
Chang,Cheng-WeiT;Liu,Hung-wen
描述了一种以甲基α-d-葡萄糖为起始原料合成标题化合物的方法。该化合物被证明是DesVI的底物，DesVI是一种依赖于Adobe Met的甲基转移酶，它催化标题化合物的N，N-二甲基化得到一种生物上有意义的不寻常的糖，地索胺。
A synthetic pathway producing the title compound starting from methyl α-d-glucose is described. This compound was shown to be a substrate for DesVI, an AdoMet-dependent methyltransferase which catalyzes N,N-dimethylation of the title compound to give a biological significant unusual sugar, desosamine.