Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: A review of the Institute Gustave Roussy experience
Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: A review of the Institute Gustave Roussy experience
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DOI：
10.1016/s0360-3016(97)00509-9
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发表时间：
1997-11-01
影响因子：
7
通讯作者：
Luboinski, B
中科院分区：
文献类型：
--
作者：
Eschwege, F;Bourhis, J;Luboinski, B
目的：这项研究的目的是提出更新的古斯塔夫研究所的经验，预测值的三个生物参数的患者与鳞状细胞癌的头部和颈部（HNSCC）治疗与放射治疗。方法和材料：三个参数已被独立调查：肿瘤细胞动力学（TS、T-pot和LI）、氧分压测量（PO 2）和固有放射敏感性（SF（2）戈伊）。在74例患者的系列研究中，未发现局部区域控制与T-pot或LI之间的关系。我们的数据还支持2戈伊时的存活分数（SF 2）不太可能预测92例患者的系列研究的临床结果。在肿瘤之间观察到PO 2测量值的差异，并且对于大多数患者，肿瘤氧合低于正常组织的氧合，但是PO 2测量值不能预测临床结果，但是考虑到进入我们研究的患者数量有限，需要进一步调查以得出明确的结论（35名患者），此外，我们能够测量10名患者的三个参数，显示PO 2，SF 2和T-pot之间没有相关性。用于评估T-pot和SF 2的方法没有为这种类型的癌症提供临床相关的预测参数，需要进一步的调查，以评估预测价值的PO 2测量和新的生物学参数的多参数方法，考虑到其他可能的临床和生物学混杂因素。(C)1997年爱思唯尔科学公司
Purpose: The aim of the study was to present the updated Institut Gustave Roussy experience of the predictive value of three biological parameters in patients with squamous cell carcinoma of the Head and Neck (HNSCC) treated with radiation therapy.Methods and Materials: Three parameters have been investigated independently: tumor cell kinetics (TS, T-pot and LI), oxygen tension measurements (PO2) and intrinsic radiosensitivity (SF(2)Gy).Results: No relationship has been found between local-regional control and T-pot or LI in a series of 74 patients, Our data also support that the surviving fraction at 2 Gy, (SF2) was unlikely to predict the clinical outcome in a series of 92 patients. Differences in PO2 measurements have been observed between tumors, and tumor oxygenation was lower than that of normal tissue for the majority of patient, However PO2 measurements did not predict clinical outcome, but further investigations are needed to draw definitive conclusions, given the limited number of patients entered in our study (35 patients), In addition, we were able to measure the three parameters in 10 patients showing no correlation between PO2, SF2 and T-pot.Conclusions: The method used to evaluate T-pot and SF2 did not provide clinically relevant predictive parameters for this type of cancer, Further investigations are needed to assess the predictive value of PO2 measurements and of new biological parameters in a multiparametric approach, taking into account other possible clinical and biological confounding factors. (C) 1997 Elsevier Science Inc.