Locus coeruleus: From global projection system to adaptive regulation of behavior.
Locus coeruleus: From global projection system to adaptive regulation of behavior.
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DOI：
10.1016/j.brainres.2016.03.001
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发表时间：
2016-08-15
期刊：
影响因子：
2.9
通讯作者：
Waterhouse B
中科院分区：
文献类型：
--
作者：
Aston-Jones G;Waterhouse B
脑干蓝斑(LC)是中枢神经系统去甲肾上腺素(NE)投射的主要来源。在非常早期的研究中，这一重要的特性被掩盖了，因为无法看到内源性单胺。瑞典科学家对单胺组织荧光方法的发展导致了大量的研究，包括1969年Loizou在《大脑研究》上发表的一篇论文。这篇论文被高度引用(使其成为本杂志50周年纪念刊的焦点)，并帮助引发了一系列大规模且持续的调查，以进一步完善我们对LC-NE系统及其对大脑功能和行为的贡献的低估。本文简要回顾了LC-NE系统在解剖学、生理学和行为学方面的研究进展。虽然它的投射普遍存在于整个中枢神经系统，但最近的研究发现，LC神经元的组织和操作领域具有惊人的特异性。这些和其他发现使我们期待未来的工作将揭示LC-NE系统的其他特征及其在规范和病理性大脑和行为过程中的作用。
The brainstem nucleus locus coeruleus (LC) is a major source of norepinephrine (NE) projections throughout the CNS. This important property was masked in very early studies by the inability to visualize endogenous monoamines. The development of monoamine histofluorescence methods by Swedish scientists led to a plethora of studies, including a paper published in Brain Research by Loizou in 1969. That paper was highly cited (making it a focal point for the 50th anniversary issue of this journal), and helped to spark a large and continuing set of investigations to further refine our understating of the LC-NE system and its contribution to brain function and behavior. This paper very briefly reviews the ensuing advances in anatomical, physiological and behavioral aspects of the LC-NE system. Although its projections are ubiquitously present throughout the CNS, recent studies find surprising specificity within the organizational and operational domains of LC neurons. These and other findings lead us to expect that future work will unmask additional features of the LC-NE system and its roles in normative and pathological brain and behavioral processes.