Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.
Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.
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补充褪黑激素可降低夜间血压，但不会影响高钠饮食的血压正常成年人的血压反应性。
DOI：
10.1152/ajpregu.00101.2023
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Lennon,ShannonL
中科院分区：
文献类型：
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作者：
RamosGonzalez,Macarena;Axler,MichaelR;Kaseman,KathrynE;Lobene,AndreaJ;Farquhar,WilliamB;Witman,MelissaA;Kirkman,DanielleL;Lennon,ShannonL
高钠饮食(HSD)会在生理扰动期间导致血压(BP)的夸大升高，从而导致交感神经激活，这与心血管风险有关。褪黑素补充剂已被证明在血压调节中发挥作用。我们的目的是研究在HSD期间服用褪黑素对24小时血压和等长握力(IHG)运动、运动后缺血(PEI)和冷加压试验(CPT)期间血压反应性的影响。22名参与者(男性11名，女性11名，年龄26.5±3.1岁，BMI：24.1±1.8 kg/m2，血压：111±9/67±7 mm Hg)被随机分为两组，分别接受为期10天的HSD(6900毫克钠/天)和10 mg/天褪黑素(HSD+MEL)或安慰剂(HSD+PL)的治疗。从第9天开始进行24小时动态血压监测。在S治疗的最后30天，测量最大自主收缩和CPT的40%时和PEI后3min的平均动脉压(MAP)。与HSD+PL相比，褪黑素对HSD的24 h MAP(HSD+PL：83±6 mm Hg；HSD+MEL：82±5 mm Hg；P=0.23)无明显影响，但降低夜间外周血压(HSD+PL：105±10 mm Hg；HSD+MEL：100±10 mm Hg；P=0.01)和中心收缩压(HSD+PL：97±9 mm Hg；HSD+MEL：93±8 mm Hg；P=0.04)。IHG期间MAP的绝对变化和百分比变化在不同条件下没有差异(均P>；0.05)。总之，补充褪黑素不会改变血压对HSD上测试的扰动的反应性，但可能有助于降低年轻健康正常血压成年人的血压。NEW&NOTEWORTHYBP的反应性在等长握力(IHG)运动、运动后缺血(PEI)和冷加压试验(CPT)中进行了评估，在高钠饮食中补充和不补充褪黑素10天。褪黑素不会改变血压正常的健康男性和女性的血压反应。然而，褪黑素确实降低了夜间外周和中心收缩压，这表明即使在血压正常的人中，褪黑素也可能有助于降低血压。
High-sodium diets (HSDs) can cause exaggerated increases in blood pressure (BP) during physiological perturbations that cause sympathetic activation, which is related to cardiovascular risk. Melatonin supplementation has been shown to play a role in BP regulation. Our aim was to examine the effects of melatonin taken during an HSD on 24-h BP and BP reactivity during isometric handgrip (IHG) exercise, postexercise ischemia (PEI), and the cold pressor test (CPT). Twenty-two participants (11 men/11 women, 26.5 ± 3.1 yr, BMI: 24.1 ± 1.8 kg/m2, BP: 111 ± 9/67 ± 7 mmHg) were randomized to a 10-day HSD (6,900 mg sodium/day) that was supplemented with either 10 mg/day of melatonin (HSD + MEL) or placebo (HSD + PL). Twenty-four-hour ambulatory BP monitoring was assessed starting onday 9. Mean arterial pressure (MAP) was quantified during the last 30 s of IHG at 40% of maximal voluntary contraction and CPT, and during 3 min of PEI. Melatonin did not change 24-h MAP (HSD + PL: 83 ± 6 mmHg; HSD + MEL: 82 ± 5 mmHg;P= 0.23) but decreased nighttime peripheral (HSD + PL: 105 ± 10 mmHg; HSD + MEL: 100 ± 10 mmHg;P= 0.01) and central systolic BP (HSD + PL: 97 ± 9 mmHg; HSD + MEL: 93 ± 8 mmHg;P= 0.04) on the HSD compared with the HSD + PL. The absolute and percent change in MAP during IHG was not different between conditions (allP> 0.05). In conclusion, melatonin supplementation did not alter BP reactivity to the perturbations tested on an HSD but may be beneficial in lowering BP in young healthy normotensive adults.NEW & NOTEWORTHYBP reactivity was assessed during isometric handgrip (IHG) exercise, postexercise ischemia (PEI), and the cold pressor test (CPT) after 10 days of a high-sodium diet with and without melatonin supplementation. Melatonin did not alter BP reactivity in healthy normotensive men and women. However, melatonin did decrease nighttime peripheral and central systolic BP, suggesting it may be beneficial in lowering BP even in those with a normal BP.