Tolerance associated gene expression following allogeneic hematopoietic cell transplantation.
Tolerance associated gene expression following allogeneic hematopoietic cell transplantation.
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DOI：
10.1371/journal.pone.0117001
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Anasetti C
中科院分区：
文献类型：
--
作者：
Pidala J;Bloom GC;Eschrich S;Sarwal M;Enkemann S;Betts BC;Beato F;Yoder S;Anasetti C
Biologic markers of immune tolerance may facilitate tailoring of immune suppression duration after allogeneic hematopoietic cell transplantation (HCT). In a cross-sectional study, peripheral blood samples were obtained from tolerant (n = 15, median 38.5 months post-HCT) and non-tolerant (n = 17, median 39.5 post-HCT) HCT recipients and healthy control subjects (n = 10) for analysis of immune cell subsets and differential gene expression. There were no significant differences in immune subsets across groups. We identified 281 probe sets unique to the tolerant (TOL) group and 122 for non-tolerant (non-TOL). These were enriched for process networks including NK cell cytotoxicity, antigen presentation, lymphocyte proliferation, and cell cycle and apoptosis. Differential gene expression was enriched for CD56, CD66, and CD14 human lineage-specific gene expression. Differential expression of 20 probe sets between groups was sufficient to develop a classifier with > 90% accuracy, correctly classifying 14/15 TOL cases and 15/17 non-TOL cases. These data suggest that differential gene expression can be utilized to accurately classify tolerant patients following HCT. Prospective investigation of immune tolerance biologic markers is warranted.
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影响因子：
15.8
作者：
Baron C;Somogyi R;Greller LD;Rineau V;Wilkinson P;Cho CR;Cameron MJ;Kelvin DJ;Chagnon P;Roy DC;Busque L;Sékaly RP;Perreault C
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DOI：
10.1016/j.clim.2013.04.013
发表时间：
2013-07
期刊：
Clinical immunology (Orlando, Fla.)
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Lowsky R
影响因子：
15.9
作者：
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Lakkis, FG
DOI：
10.4049/jimmunol.1100714
发表时间：
2011-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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通讯作者：
Speed, TP