Evidence for molecular differences in prostate cancer between African American and Caucasian men.
Evidence for molecular differences in prostate cancer between African American and Caucasian men.
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DOI：
10.1158/1078-0432.ccr-13-2265
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发表时间：
2014-09-15
期刊：
影响因子：
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通讯作者：
Robinson BD
中科院分区：
文献类型：
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作者：
Khani F;Mosquera JM;Park K;Blattner M;O'Reilly C;MacDonald TY;Chen Z;Srivastava A;Tewari AK;Barbieri CE;Rubin MA;Robinson BD
比较非裔美国人和白人男性前列腺癌中ERG重排、PTEN缺失、SPINK 1过表达和SPOP突变的频率。将105例非裔美国人（AAM）根治性前列腺切除术标本的优势肿瘤结节与113例高加索人（CaM）的优势结节进行比较。两组的临床和病理特征相似。SPINK 1过表达通过免疫组化、ERG重排和PTEN缺失通过FISH、SPOP突变通过桑格测序进行评估。在CaM中的48/113个肿瘤（42.5%）和AAM中的29/105个肿瘤（27.6%）中确定了ERG重排（p=0.024）。在CaM中的19/96个肿瘤（19.8%）和AAM中的7/101个肿瘤（6.9%）中观察到PTEN缺失（p=0.011）。SPINK 1过表达存在于CaM中的9/110个肿瘤（8.2%）和AAM中的25/105个肿瘤（23.4%）中（p=0.002）。在CaM的8/78（10.3%）肿瘤和AAM的4/88（4.5%）肿瘤中鉴定出SPOP突变（p=0.230）。校正年龄、BMI、Gleason评分和病理分期后，ERG重排和SPINK 1过表达仍有显著差异（分别为p=0.018和p=0.008），PTEN缺失和SPOP突变的差异接近显著性（分别为p=0.061和p=0.087）。前列腺癌之间在AAM和CaM中存在显著的分子差异。SPINK 1过表达，一种与更具侵袭性的前列腺癌相关的改变，在AAM中更常见，而ERG重排和PTEN缺失在该队列中不太常见。进一步的研究是必要的，以确定这些分子差异是否解释了这两个种族之间的发病率和死亡率的差异。
To compare the frequency of ERG rearrangement, PTEN deletion, SPINK1 overexpression, and SPOP mutation in prostate cancer in African American and Caucasian men. Dominant tumor nodules from radical prostatectomy specimens of 105 African American men (AAM) were compared to 113 dominant nodules from Caucasian men (CaM). Clinical and pathologic characteristics of the two groups were similar. SPINK1 overexpression was evaluated by immunohistochemistry, ERG rearrangement and PTEN deletion by FISH, and SPOP mutation by Sanger sequencing. ERG rearrangement was identified in 48/113 tumors (42.5%) in CaM and 29/105 tumors (27.6%) in AAM (p=0.024). PTEN deletion was seen in 19/96 tumors (19.8%) in CaM and 7/101 tumors (6.9%) in AAM (p=0.011). SPINK1 overexpression was present in 9/110 tumors (8.2%) in CaM and 25/105 tumors (23.4%) in AAM (p=0.002). SPOP mutation was identified in 8/78 (10.3%) tumors in CaM and 4/88 (4.5%) tumors in AAM (p=0.230). When adjusted for age, BMI, Gleason score, and pathologic stage, ERG rearrangement and SPINK1 overexpression remain significantly different (p=0.018 and p=0.008, respectively), and differences in PTEN deletion and SPOP mutation approach significance (p=0.061 and p=0.087, respectively). Significant molecular differences exist between prostate cancers in AAM and CaM. SPINK1 overexpression, an alteration associated with more aggressive prostate cancers, was more frequent in AAM, while ERG rearrangement and PTEN deletion were less frequent in this cohort. Further investigation is warranted to determine if these molecular differences explain some of the disparity in incidence and mortality between these two ethnic groups.