Sex of the animal impacts responses to angiotensin II, oxidative stress levels, and nitric oxide bioavailability.
Sex of the animal impacts responses to angiotensin II, oxidative stress levels, and nitric oxide bioavailability.
复制标题
动物的性别影响对血管紧张素 II 的反应、氧化应激水平和一氧化氮生物利用度。
DOI：
10.1161/hypertensionaha.111.171017
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Sullivan,JenniferC
中科院分区：
文献类型：
--
作者：
Brinson,KrystalN;Sullivan,JenniferC
Oxidative stress has been implicated in the pathogenesis of renal and cardiovascular diseases; however, there is still much to be learned. It is against this background that we read with great interest the article titled,“Superoxide Dismutase 1 Limits Renal Microvascular Remodeling and Attenuates Arteriole and Blood Pressure Responses to Angiotensin II via Modulation of Nitric Oxide Bioavailability,” by Carlström et al. 1 The goal of this article was to determine the functional role of superoxide dismutase 1 (SOD1) in regulating renal microvascular function and blood pressure responses to angiotensin (Ang) II. The authors found that SOD1 knockout mice had a greater initial increase in blood pressure to chronic Ang II compared with wild-type control mice. In addition, renal afferent arterioles from SOD1 knockout mice were significantly more sensitive to acute Ang II–induced vasoconstriction compared with wild type, whereas arterioles from SOD1 transgenic mice were less sensitive to Ang II versus controls. Altered vascular responsiveness was likely attributed to low levels of NO bioavailability in arterioles from SOD1-knockout mice and enhanced levels of superoxide.Although the authors are to be commended on their excellent work, we would like to call attention to the fact that experiments were conducted using both male and female SOD1-transgenic, SOD1 knockout, and wild-type littermate mice with an equal distribution of both sexes in all of the experiments. Based on known sex differences in blood pressure and vascular responses to Ang II, 2 sex differences in NO bioavailability, 3 and sex differences in oxidative stress and antioxidant potential, 4 the inclusion of both sexes may be a confounding factor in the study. In fact, if only males had been included, the differences between the SOD1-knockout and transgenic mice and the appropriate wild-type control groups may have been more dramatic. For example, female experimental animals have been shown to be less sensitive to Ang II–induced hypertension, therefore, it would be interesting to know whether the blood pressure data in Figure 2 of their article included 2 males and 3 females or 3 males and 2 females. The inclusion of both sexes may also contribute to the
